Protective Effect of Squalene against Isoproterenol-Induced Myocardial Infarction in Rats
-
- Farvin Koduvayur Habeebullah Sabeena
- Biochemistry and Nutrition Division, Central Institute of Fisheries Technology
-
- Anandan Rangasamy
- Biochemistry and Nutrition Division, Central Institute of Fisheries Technology
-
- Sankar Thazhakot Vasunambisan
- Biochemistry and Nutrition Division, Central Institute of Fisheries Technology
-
- Nair Pullanniyil Gopalan Viswanathan
- Biochemistry and Nutrition Division, Central Institute of Fisheries Technology
この論文をさがす
抄録
The protective effect of squalene on membrane function and mineral status was examined in isoproterenol-induced myocardial infarction in male albino rats. The pretreatment with squalene at 2% level along with feed significantly reduced the isoproterenol-induced rise in the levels of plasma diagnostic marker enzymes (ALT, AST, LDH and CPK). It counteracted isoproterenol-induced lipid peroxidation in plasma and heart tissue, and maintained the level of reduced glutathione in the heart tissue at near normalcy. Supplementation of squalene also exerted membrane stabilizing action against isoproterenol-induced myocardial infarction by maintaining the activities of membrane-bound ATPases (Na+, K+ ATPase and Ca2+ ATPase) in heart tissue and the mineral status (sodium, potassium and calcium) in plasma and heart tissue at near normal levels. The cardioprotective effect of squalene might be ascribable to its antioxidant nature and membrane stabilizing property.
収録刊行物
-
- Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｂｉｏｃｈｅｍｉｓｔｒｙ ａｎｄ Ｎｕｔｒｉｔｉｏｎ
-
Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｂｉｏｃｈｅｍｉｓｔｒｙ ａｎｄ Ｎｕｔｒｉｔｉｏｎ 37 (2), 55-60, 2005
一般社団法人 日本酸化ストレス学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001204670861696
-
- NII論文ID
- 130004466428
-
- ISSN
- 18805086
- 09120009
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- Crossref
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可