Extension of lifespan and protection against oxidative stress by an antioxidant herb mixture complex (KPG-7) in Caenorhabditis elegans

• Moriwaki Takahito

  Laboratory of Stress Response Biology, Graduate School of Science, Kyoto University

• Kato Seiji

  Laboratory of Stress Response Biology, Graduate School of Science, Kyoto University

• Kato Yuichi

  Laboratory of Stress Response Biology, Graduate School of Science, Kyoto University

• Hosoki Ayaka

  Laboratory of Stress Response Biology, Graduate School of Science, Kyoto University

• Zhang-Akiyama Qiu-Mei

  Laboratory of Stress Response Biology, Graduate School of Science, Kyoto University

書誌事項

タイトル別名

• Extension of lifespan and protection against oxidative stress by an antioxidant herb mixture complex (KPG-7) in <i>Caenorhabditis elegans</i>

抄録

Excessive generation of reactive oxygen species within cells results in oxidative stress. Furthermore, accumulation of reactive oxygen species has been shown to reduce cell longevity. Many dietary supplements are believed to have anti-aging effects. The herb mixture KPG-7 contains several components with antioxidant activity. We aim to clarify the mechanisms responsible for the antioxidant activity of KPG-7 and to establish whether KPG-7 has an anti-aging effect. We examined whether dietary supplementation with KPG-7 could provide protection against oxidative stress, extend lifespan, and delay aging in Caenorhabditis elegans (C. elegans). We found that KPG-7 extended lifespan and delayed aging in adult C. elegans. The expression of oxidation resistance 1 protein was induced by juglone and this effect was significantly suppressed in KPG-7-treated. In addition, the amount of oxidized protein was significantly lower in KPG-7-treated worms than untreated worms. Furthermore, locomotive activity was increased in C. elegans at 3 days of age following the treatment with KPG-7. On the other hand, the level of cellular ATP was lower at 3 days of age in worms treated with KPG-7 than in untreated worms. KPG-7 increases lifespan and delays aging in C. elegans, well corresponding to its activity to protect against oxidative stress.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ 53 (2), 81-88, 2013

  一般社団法人　日本酸化ストレス学会

キーワード

• oxidative stress
• <i>C. elegans</i>
• aging
• herb mixture
• antioxidant

詳細情報

• CRID: 1390001204672282496
• NII論文ID: 130004466721
• DOI: 10.3164/jcbn.13-11
• COI: 1:STN:280:DC%2BC2c%2Fgs1Kruw%3D%3D
• ISSN: 18805086
• ISSN: 09120009
• Web Site: https://search.jamas.or.jp/link/ui/2014115245
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可