Possible role of the RhoC/ROCK pathway in progression of clear cell renal cell carcinoma
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- ABE Hideyuki
- Department of Urology, Dokkyo Medical University
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- KAMAI Takao
- Department of Urology, Dokkyo Medical University
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- TSUJII Toshihiko
- Department of Urology, Dokkyo Medical University
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- NAKAMURA Fumihiko
- Department of Urology, Dokkyo Medical University
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- MASHIDORI Tomoko
- Department of Urology, Dokkyo Medical University
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- MIZUNO Tomoya
- Department of Urology, Dokkyo Medical University
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- TANAKA Miho
- Department of Urology, Dokkyo Medical University
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- TATSUMIYA Katsuhisa
- Department of Urology, Dokkyo Medical University
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- FURUYA Nobutaka
- Department of Urology, Dokkyo Medical University
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- MASUDA Akinori
- Department of Urology, Dokkyo Medical University
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- YAMANISHI Tomonori
- Department of Urology, Dokkyo Medical University
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- YOSHIDA Ken-Ichiro
- Department of Urology, Dokkyo Medical University
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抄録
To clarify the role of the Rho small GTP-binding protein (Rho) and its major downstream target, ROCK (Rho-associated serine-threonine protein kinase), in progression of renal cell carcinoma (RCC), we examined mRNA expression for Rho and ROCK genes in surgical specimen of RCC tissues from 78 Japanese patients and in the corresponding non-tumor tissues originating from the same patient using a real-time reverse transcription polymerase chain reaction (RT-PCR). Expression of mRNA for RhoA did not differ between tumor and non-tumor tissues. RhoB mRNA expression was higher in the tumor (P < 0.05), but expression was not associated with tumor grade, stage, or prognosis. However, degree of RhoC and ROCK mRNA expression was related to tumor grade (P < 0.05) and stage (P < 0.0001). A positive relationship was seen between expression of mRNA for RhoC and that for ROCK in tumor tissues (P < 0.0001). Kaplan-Meier plots showed high RhoC and ROCK mRNA expression to be negatively associated with overall survival (P < 0.0001). Multivariate analysis showed mRNA expression of RhoC and ROCK to be independent poor prognostic factors concerning overall survival. Our findings implicate the RhoC/ROCK pathway in carcinogenesis and progression of RCC, indicating that RhoC/ROCK may be a useful prognostic marker and a possible molecular target for treatment of the disease.
収録刊行物
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- Biomedical Research
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Biomedical Research 29 (3), 155-161, 2008
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詳細情報 詳細情報について
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- CRID
- 1390282679877886464
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- NII論文ID
- 130004470709
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- ISSN
- 1880313X
- 03886107
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可