Polymorphous Light Eruption. Histopathologic and Immunohistochemical Findings in Primary and Reproduced Lesions.

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  • 多形日光疹およびその誘発皮疹の免疫組織化学的検討
  • —Histopathologic and Immunohistochemical Findings in Primary and Reproduced Lesions—
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Abstract

The histopathologic and immunohistochemical findings were investigated in primary and reproduced lesions from 4 patients with polymorphous light eruption (PLE). The diagnosis of PLE was made based on the clinical features and the findings of provocative phototests. Two minimal erythema doses of UVB were irradiated daily for 3 consecutive days to reproduce PLE. In the primary and reproduced lesions, dermal perivascular lymphocytic infiltrates and hydropic degeneration of basal cells were most frequently observed. Dermal lymphocytes were almost only T cells, in which the CD4 subset was predominant over the CD8 subset in both lesions. ICAM-1 was positive in the endothelial cells of half the cases, and was also positively seen in the keratinocytes. These histopathological and immunohistochemical results suggests that the pathogenesis of PLE is thus due to a delayed type of hypersensitivity.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 60 (4), 510-513, 1998

    Western Division of Japanese Dermatological Association

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