Oral Administration of Heat-Killed& Lactobacillus gasseri OLL2809 Reduces Cedar Pollen Antigen-Induced Peritoneal Eosinophilia in Mice
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- Sashihara Toshihiro
- Food Science Institute, Division of Research and Development, Meiji Dairies Corporation
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- Ikegami Shuji
- Food Science Institute, Division of Research and Development, Meiji Dairies Corporation
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- Sueki Natsuko
- Food Science Institute, Division of Research and Development, Meiji Dairies Corporation
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- Yamaji Taketo
- Food Science Institute, Division of Research and Development, Meiji Dairies Corporation
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- Kino Kohsuke
- Food Science Institute, Division of Research and Development, Meiji Dairies Corporation
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- Taketomo Naoki
- Food Science Institute, Division of Research and Development, Meiji Dairies Corporation
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- Gotoh Minoru
- Department of Otolaryngology, Nippon Medical School, Chiba Hokusoh Hospital
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- Okubo Kimihiro
- Department of Otorhinolaryngology, Nippon Medical School
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Background: Lactobacillus gasseri OLL2809 strongly stimulates the production of interleukin (IL)-12 (p70) by innate immune cells. Thus, it is expected to ameliorate allergic diseases. We investigated whether the oral administration of heat-killed L. gasseri OLL2809 suppressed eosinophilia in cedar pollen antigen-challenged mice.<br> Methods: BALB/c mice sensitized with Japanese cedar pollen extract were intraperitoneally challenged with the same extract. The mice were orally given heat-killed L. gasseri OLL2809 at doses of 0.5, 1, or 2mg/day throughout the experimental period (21 d). After 24 hours of the challenge, the eosinophil number and cytokine levels in the peritoneal lavage fluid and the serum antigen-specific IgG levels were determined.<br> Results: On administering varying amounts of heat-killed L. gasseri OLL2809, the number of eosinophils among the total number of cells was significantly reduced in all groups. In addition, the eosinophil number significantly decreased, and the eosinophil-suppression rate significantly increased by 44% in the 2-mg group. Although the serum immunoglobulin (Ig) G2a and IgG1 levels were not affected, the IgG2a/IgG1 ratio increased significantly in the 2-mg group compared with that of the control group. Furthermore, the administration of heat-killed L. gasseri OLL2809 resulted in the induction of IL-2 and reduction in granulocyte-macrophage colony-stimulating factor levels in peritoneal lavage fluid.<br> Conclusions: We demonstrated that the oral administration of heat-killed L. gasseri OLL2809 suppresses eosinophilia via the modulation of Th1/Th2 balance. These observations suggested that heat-killed L. gasseri OLL2809 might potentially ameliorate the increased number of eosinophils in patients with Japanese cedar pollinosis.<br>
収録刊行物
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- Allergology International
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Allergology International 57 (4), 397-403, 2008
一般社団法人日本アレルギー学会
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詳細情報 詳細情報について
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- CRID
- 1390282679610632064
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- NII論文ID
- 10025108655
- 130004477001
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- NII書誌ID
- AA11091750
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- COI
- 1:CAS:528:DC%2BD1MXnsFSiuw%3D%3D
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- ISSN
- 14401592
- 13238930
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- PubMed
- 18946235
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 使用不可