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- Izuhara Kenji
- Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School
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- Arima Kazuhiko
- Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School
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- Ohta Shoichiro
- Department of Laboratory Medicine, Saga Medical School
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- Suzuki Shoichi
- Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School
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- Inamitsu Masako
- Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School
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- Yamamoto Ken-ichi
- Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School
この論文をさがす
抄録
Periostin, an extracellular matrix protein belonging to the fasciclin family, has been shown to play a critical role in the process of remodeling during tissue/organ development or repair. Periostin functions as a matricellular protein in cell activation by binding to their receptors on cell surface, thereby exerting its biological activities. After we found that periostin is a downstream molecule of interleukin (IL)-4 and IL-13, signature cytokines of type 2 immune responses, we showed that periostin is a component of subepithelial fibrosis in bronchial asthma, the first formal proof that periostin is involved in allergic inflammation. Subsequently, a great deal of evidence has accumulated demonstrating the significance of periostin in allergic inflammation. It is of note that in skin tissues, periostin is critical for amplification and persistence of allergic inflammation by communicating between fibroblasts and keratinocytes. Furthermore, periostin has been applied to development of novel diagnostics or therapeutic agents for allergic diseases. Serum periostin can reflect local production of periostin in inflamed lesions induced by Th2-type immune responses and also can predict the efficacy of Th2 antagonists against bronchial asthma. Blocking the interaction between periostin and its receptor, αv integrin, or down-regulating the periostin expression shows improvement of periostin-induced inflammation in mouse models or in in vitro systems. It is hoped that diagnostics or therapeutic agents targeting periostin will be of practical use in the near future.<br>
収録刊行物
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- Allergology International
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Allergology International 63 (2), 143-151, 2014
一般社団法人日本アレルギー学会