A regenerative approach for partial tracheal defects, an in vivo canine model

• Yamashita Masaru

  Department of Otolaryngology -- Head and Neck Surgery, Graduate School of Medicine, Kyoto University Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, U.S.A.

• Kanemaru Shin-ichi

  Department of Otolaryngology -- Head and Neck Surgery, Graduate School of Medicine, Kyoto University

• Hirano Shigeru

  Department of Otolaryngology -- Head and Neck Surgery, Graduate School of Medicine, Kyoto University

• Tamura Yoshihiro

  Department of Otolaryngology -- Head and Neck Surgery, Graduate School of Medicine, Kyoto University

• Umeda Hiroo

  Department of Otolaryngology -- Head and Neck Surgery, Graduate School of Medicine, Kyoto University

• Ohno Tsunehisa

  Department of Otolaryngology -- Head and Neck Surgery, Graduate School of Medicine, Kyoto University

• Suehiro Atsushi

  Department of Otolaryngology -- Head and Neck Surgery, Graduate School of Medicine, Kyoto University

• Omori Koich

  Department of Otolaryngology, Fukushima Medical University

• Nakamura Tatsuo

  Department of Bioartificial Organs, Institute for Frontier Medical Sciences, Kyoto University

• Ito Juichi

  Department of Otolaryngology -- Head and Neck Surgery, Graduate School of Medicine, Kyoto University

抄録

In the field of head and neck surgery, tracheal resection is frequently required for patients with cancer or trauma. There are several approaches for reconstructing the tracheal wall, but almost all require repeated skilled surgeries, which intend to fill the defect and create new airway space using autologous or artificial grafts.<BR>Regenerative medicine has made remarkable progress and has been applied clinically in some organs. Thus in this study, the usefulness of a tissue engineering approach for tracheal reconstruction was evaluated. A partial defect was created in canine cervical tracheas. A scaffold made of polypropylene and collagen sponge was sutured at the defect site. Postoperative status was evaluated by endoscopy, radiography, and histology. In all five cases, epithelialization of the scaffold luminal surface was observed without deformity or complications. Histological data also supported the functional regeneration of the trachea using this approach. This simple tissue engineering approach is a good method for reconstruction of the trachea with partial defects.

収録刊行物

• Inflammation and Regeneration

  Inflammation and Regeneration 27 (6), 570-574, 2007

  一般社団法人 日本炎症・再生医学会

キーワード

• artificial trachea
• polypropylene
• collagen
• scaffold
• tracheal regeneration

詳細情報

• CRID: 1390282680233632896
• NII論文ID: 130004482198
• NII論文ID: 10022602018
• NII書誌ID: AA11508953
• DOI: 10.2492/inflammregen.27.570
• ISSN: 18808190
• ISSN: 18809693
• NDL書誌ID: 9294271
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9294271
• Web Site: https://search.jamas.or.jp/link/ui/2008171360
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可