Serum Levels of TGF-β1 and MCP-1 as Biomarkers for Progressive Coal Workers’ Pneumoconiosis in Retired Coal Workers: A Three-year Follow-up Study
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- LEE Jong Seong
- Occupational Lung Diseases Institute, Korea Workers’ Compensation and Welfare Service, Republic of Korea
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- SHIN Jae Hoon
- Occupational Lung Diseases Institute, Korea Workers’ Compensation and Welfare Service, Republic of Korea
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- LEE Kyung Myung
- Forensic DNA Center, NFS, Republic of Korea
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- HWANG Ju-Hwan
- Occupational Lung Diseases Institute, Korea Workers’ Compensation and Welfare Service, Republic of Korea
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- BAEK Jin Ee
- Occupational Lung Diseases Institute, Korea Workers’ Compensation and Welfare Service, Republic of Korea
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- KIM Ji Hong
- Ansan WCI Hospital, Korea Workers’ Compensation and Welfare Service, Republic of Korea
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- CHOI Byung-Soon
- Occupational Lung Diseases Institute, Korea Workers’ Compensation and Welfare Service, Republic of Korea
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Various cytokines activated by the inhalation of coal dust may mediate inflammation and lead to tissue damage. Objective of this study was to examine the relationships between coal workers’ pneumoconiosis (CWP) progression over a 3 yr period and the serum levels of cytokines in 85 retired coal workers. To investigate the relevance of serum cytokines in CWP, serum levels of interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α), transforming growth factor–beta1 (TGF-β1), and monocyte chemotactic protein-1 (MCP-1) as progressive CWP biomarkers were studied in relation to the progression of pneumoconiosis over a 3 yr period in 85 patients with CWP. CWP progression was evaluated through paired comparisons of chest radiographs. Median levels of TGF-β1 and MCP-1 were significantly higher in subjects with progressive CWP than in those without CWP progression. The area under the ROC curve for TGF-β1 (0.693) and MCP-1 (0.653) indicated that these cytokines could serve as biomarkers for the progression of CWP. Serum TGF-β1 levels were related to the progression of CWP (β=0.247, p=0.016). The results suggest that high serum levels of TGF-β1 and MCP-1 are associated with the progression of CWP.
収録刊行物
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- Industrial health
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Industrial health 52 (2), 129-136, 2014
独立行政法人 労働者健康安全機構 労働安全衛生総合研究所
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詳細情報 詳細情報について
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- CRID
- 1390001204281565568
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- NII論文ID
- 130004483611
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- NII書誌ID
- AA00672955
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- COI
- 1:STN:280:DC%2BC2czotFSrtg%3D%3D
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- ISSN
- 18808026
- 00198366
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- NDL書誌ID
- 025399055
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- PubMed
- 24464026
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可