Anti-diarrheal effects of wood creosote pill preparation compounded with four crude drugs on castor oil-induced diarrhea in rats and the role of crude drugs in the expression of the efficacy

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  • 馬場 達也
    大幸薬品株式会社生産部 Present address: Taiko Pharmaceutical Co. Ltd.
  • NISHINO Takao
    Osaka University of Pharmaceutical Sciences
  • TANI Tadato
    Department of Kampo-Pharmaceutics, Institute of Natural Medicine, University of Toyama

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Wood creosote pill preparation, in which 4 crude drug powders, Gambir, Phellodendri Cortex, Glycyrrhizae Radix, and Citri Unshiu Pericarpium are compounded, has been used for diarrhea. In the present study, the significance of the compounding of these crude drug powders was examined in castor oil-induced diarrhea model in rats.<br>Oral administration of small wood creosote pill (P4Rx5) exerted anti-diarrheal action for up to 3 hours and intestinal peristaltic motility-suppressive action, which was assessed by charcoal meal test. These suppressive actions were not noted in the groups of the rats receiving wood creosote alone at a dose level (11 mg/kg) that is contained in P4Rx5. From these findings, it was revealed that crude drugs compounded were responsible for the anti-diarrheal and intestinal peristaltic motility-suppressive actions of P4Rx5.<br>Pharmacological actions were examined for variant pills (without one of the crude drug powders), revealing that Citri Unshiu Pericarpium was responsible for retention of the anti-diarrheal effects and the suppression of castor oil-induced intestinal peristaltic motility by P4Rx5. Furthermore, it was found that the compounded crude drug powders increased the AUC of guaiacol (a major anti-diarrheal component of wood creosote), being involved in the intestinal peristaltic motility-suppressive action of P4Rx5. The results obtained in the present study may provide evidence supporting the usefulness of the compounding of the crude drugs in traditional wood creosote pills such as “Seiro-gan”, and give a rationale for development of new preparations compounding wood creosote with crude drug powders.

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