書誌事項
- タイトル別名
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- Immunopathological Study in Thymoma Patients
- 胸腺腫患者の免疫異常の検討--リンパ球の動態を中心として
- キョウセンシュ カンジャ ノ メンエキ イジョウ ノ ケントウ リンパキュウ
- —リンパ球の動態を中心として—
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抄録
An immunopathological study of 21 patients with thymoma was perfomed. The median age was 51, with range of 26-69 years. There were 11 male and 10 female. All thymoma of this series were detected by thymectomy, biopsy and necropsy. Myasthenia gravis was present in 10 patients, including 1 patient who also had pure red cell aplasia. Sjögren's syndrome was present in 2 cases, and pure red cell aplasia in 1. Four cases were predominantly epitherial cellular type, 9 were lymphocytic and 8 were mixed. The average of circulating lymphocyte counts of the thymoma patients was 2986/cmm and was higher than normal. There was an increase in the number of non-T and non-B lymphocyte (null-lymphocyte). Both counts of T and B-lymphocytes were within normal value. The response of the peripheral lymphocyte in thymoma patients in vitro against PHA-P stimulation was significantly suppressed than healthy lymphocyte. Antinuclear antibody was found in 75% serum of thymoma patients.<br>In 9 thymoma obtained at thymectomy, the median percentage of T-lymphocyte was 72 and B-lymphocyt was 4. Sixteen patients were studied prospectively before and after thymectomy, and there was a decrease in peripheral lymphocytes after thymectomy that was statistically significant. The proportion of decreased lymphocytes after thymectomy was mainly null-lymphocytes. The thymoma patients had abnormality of humoral and cellular immunity.
収録刊行物
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- 臨床血液
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臨床血液 21 (2), 189-194, 1980
一般社団法人 日本血液学会
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詳細情報 詳細情報について
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- CRID
- 1390282680013592576
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- NII論文ID
- 130004498178
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- NII書誌ID
- AN00252940
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- COI
- 1:STN:280:Bi6D3M%2FgsVY%3D
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- ISSN
- 18820824
- 04851439
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- NDL書誌ID
- 2210668
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- PubMed
- 7411864
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可