多数のSea-Blue Histiocytesがみられた慢性骨髄性白血病の一例

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タイトル別名
  • Sea-Blue Histiocytes in Bone Marrow with Chronic Myelocytic Leukemia
  • 多数のSea-Blue Histiocytesがみられた慢性骨髄性白血病の1例
  • タスウ ノ Sea Blue Histiocytes ガ ミラレタ マンセイ

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In 1966 Albrecht first reported Gaucher-like cells in bone marrow smears of chronic myelocytic leukemia patients. Additional informations have been reported by Smith, Kattlove, and Sawitsky. Although a considerable number of publicatons have appeared in recent years, little is known about the mechanism of development of Gaucher-like cells or sea-blue histiocytes in the bone marrow of patients with acute or chronic myelocytic leukemia, or idiopathic thrombocytopenic purpura.<br>This study was designed to elucidate the mechanism of sea-blue histiocyte formation in the bone marrow. Histochemical, ultrastructural, and leukokinetic studies were performed on a patient with chronic myelocytic leukemia in order to find the relationship between the appearance of sea-blue histiocytes in the bone marrow and the granulocyte turnover rate. The high incidence of sea-blue histiocytes was considered to be resulted from the increased granulocyte turnover rate, which was thought to run in parallel with the glycolipid turnover rate. It was concluded that the excess glycolipid was accumulated and stored in reticuloendothelial cells.

収録刊行物

  • 臨床血液

    臨床血液 22 (5), 694-700, 1981

    一般社団法人 日本血液学会

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