IgG型寒冷凝集素症の一例

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タイトル別名
  • A Case of Agglutinin Disease
  • IgG型寒冷凝集素症の1例
  • IgGガタ カンレイ ギョウシュウソショウ ノ 1レイ

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抄録

A case of IgG cold agglutinin disease was studied for its immunoglobulin class and mechanisms of hemolysis. A 42 year-old woman was admitted to our clinic because of the sudden onset of severe hemolytic anemia. Cold agglutinin was detected at the titer of 1:1024. The elution studies of her cold agglutinin and the 2-ME treatment of her serum showed that its immunoglobulin class was IgG κλ type. Repeated Coombs' test determined by either anti-Ig or anti-C3 antiserum were negative and a complement consumption test with her serum was also negative. These results suggested that her IgG cold agglutinin did not activate complement system. Furthermore, auto-rosette formation between mononuclear cell and erythrocytes was observed after incubating whole heparinized blood at 4°C. Since these rosettes were still observed even when Ca++ was depleted by the addition of EDTA, the rosettes were seemed to be formed through the interaction with Fc-receptors of mononuclear cells but not with C3-receptors. After administration of larger dosis of prednisolone, hemolysis improved and numbers of auto-rosette decreased.

収録刊行物

  • 臨床血液

    臨床血液 23 (12), 1884-1888, 1982

    一般社団法人 日本血液学会

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