書誌事項
- タイトル別名
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- A Case of Double Malignant Neoplasm with Posthepatitis Aplastic Anemia and Stevens-Johnson like Syndrome Induced by Drug
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抄録
A 63-year-old woman was diagnosed as non-Hodgkin's lymphoma (small cell type) by histopathological findings of the resected specimen of the rectum in 1980 and treated by some chemotherapeutics. In March 1983, she was pointed out to have the enlargement of mediastinal lymphnode and abnormal accumulation on Ga scyncygram. She was diagnosed as relapse of malignant lymphoma and treated with 2 courses of CHOP regimen. At that time, she was also pointed out the existence of carcinoma colli uteri and required hysterectomy. The operation was done after confirmation of the improvement by means of myelosuppresive chemotherapy. After the operation slight fever developed, and she was treated with cephazolin and micronomycin for 3 days, and then amoxicillin was administered. Next day, high fever developed and sore throat, hoarsness, exanthema, erosion in oral cavity, cheilitis, conjunctivitis, DIC, elevation of GOT, GPT and pancytopenia developed one after another. The findings of bone marrow biopsy revealed disappearence of hematopoietic cells. In spite of a large dose corticosteroid therapy, adult respiratory distress syndrome developed and died of respiratory and renal failure.<br>It was supposed that her various manifestations were induced by drugs, especially by amoxicillin, on judging from clinical course.
収録刊行物
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- 臨床血液
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臨床血液 26 (6), 936-942, 1985
一般社団法人 日本血液学会