Marked Bone Marrow Necrosis Preceding Acute Myeloblastic Leukemia in Childhood.
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- SUGIYAMA Hiromi
- The Department of Pediatrics, Shinshu University School of Medicine
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- NAKAHATA Tatsutoshi
- The Department of Pediatrics, Shinshu University School of Medicine
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- KUBO Tetsuo
- The Department of Pediatrics, Shinshu University School of Medicine
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- KIKUCHI Toshimi
- The Department of Pediatrics, Shinshu University School of Medicine
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- AMANO Yoshiro
- The Department of Pediatrics, Shinshu University School of Medicine
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- OKUMURA Nobuo
- Central Clinical Laboratories, Shinshu University School of Medicine
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- KOMIYAMA Atsushi
- The Department of Pediatrics, Shinshu University School of Medicine
Bibliographic Information
- Other Title
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- 著明な骨髄壊死が先行した急性骨髄性白血病の１小児例
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Abstract
A 3-year-old boy was transferred to our hospital because of fever, abdominal pain and severe systemic bone pain on October 16, 1989. Hematological examination showed hemoglobin 8.7 g/dl, white blood cell count 5300/μl with 9% neutrophils and platelet count 5.5×104/μl. Bone marrow aspiration and biopsy revealed markedly necrotic cells. Blood chemistry showed transient elevation of CRP, serum LDH, FDP, FDP-Ddimer and fibrinogen. Tc99m pyrophosphate bone scanning showed multiple uptake spots in various bone. Although the sign of fever, abdominal pain and bone pain disappeared spontaneously after three weeks, anemia persisted. About two months later from bone marrow necrosis, abnormal cells appeared in the bone marrow. A diagnosis of AML (M3) was made and a combination chemotherapy started. This case is remarkable for elevation of acute phase protein in assosiation with bone marrow necrosis.
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 32 (9), 991-995, 1991
The Japanese Society of Hematology
