Aplastic Anemia and Erythropoietin

• HASEGAWA M.

  Dept. of Medicine, Keio University School of Medicine Tokyo

• MATSUKI Y.

  Dept. of Medicine, Keio University School of Medicine Tokyo

• TOYAMA K.

  Dept. of Medicine, Keio University School of Medicine Tokyo

• OZAWA S.

  Dept. of Medicine, Keio University School of Medicine Tokyo

• ANDO Y.

  Dept. of Medicine, Keio University School of Medicine Tokyo

抄録

Serum erythropoietin levels of various anemic patients, polycythemic and anemic rabbits were determined by Fried's, Matoth's and Krantz's method. No discrepancy of the results in accordance with these three methods was obtained in all cases except for aplastic anemia, in which the erythropoietin activities were found to be elevated by Fried's method, while lowered by both Matoth's and Krantz's method.<br>The responses of the bone marrow cells of patients with aplastic anemia to the sera from (a) normal volunteers, (b) patients with chronic bleeding and (c) patients with aplastic anemia were studied by Krantz's method. The heme Fe⁵⁹ synthesis was increased when cultured with serum (b), but decrease with serum (c). These responses were almost epual to those seen in normal bone marrow cell cultures.<br>Parenteral administration of erythropoietin-rich plasma obtained from patients with chronic bleeding resulted in apparent increase of erythroid series in most cases with aplastic anemia, while administration of normal plasma showed no favorable effects.<br>The role of erythropoietin in aplastic anemia was discussed.

収録刊行物

• 臨床血液

  臨床血液 9 (5), 635-638, 1968

  一般社団法人 日本血液学会

詳細情報

• CRID: 1390282680009477120
• NII論文ID: 130004501973
• DOI: 10.11406/rinketsu.9.635
• ISSN: 18820824
• ISSN: 04851439
• 本文言語コード: en
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可