熱測定法を用いたリスペリドンと市販飲料との配合変化試験および茶葉タンニンとの相互作用

DOI NDLデジタルコレクション 被引用文献4件 参考文献19件

書誌事項

タイトル別名
  • Evaluation of Compatibility of Risperidone with Soft Drinks and Interactions of Risperidone with Tea Tannin using Isothermal Titration Microcalorimetry

この論文をさがす

抄録

Compatibility between risperidone and soft drinks was examined by means of isothermal titration microcalorimetry, and the interaction of risperidone with tea tannin- (-)-epigallocatechin, (-)-epicatechin, theaflavin and their gallates-was investigated thermodynamically. Risperidone exothermically bound to tea tannin monomers with a binding affinity of 103-104 M-1 in aqueous solution to form an insoluble complex at a 1:1 molar ratio. The binding reaction was characterized by small enthalpy and entropy changes, reflecting hydrophobic and van der Waal's interactions.<br>After mixing Risperdal® liquid (1 mg/mL risperidone oral solution) with soft drinks containing tannin-such as green tea, black tea and oolong tea, there was an immediate decrease in the risperidone content and the mixtures became cloudy. The heat effect of risperidone titrated into these soft drinks was exothermic and proportional to the quantity of the complex formed in the mixture. However, no significant heat effect was noted when risperidone was titrated into drinks in PET bottles that do not contain tea tannin, such as mineral water and an infusion of parched barley. Isothermal titration microcalorimetry is thus a rapid and effective method for evaluating the compatibility and physico-chemical interactions of drugs.

収録刊行物

  • 医療薬学

    医療薬学 32 (3), 190-198, 2006

    一般社団法人日本医療薬学会

被引用文献 (4)*注記

もっと見る

参考文献 (19)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ