Expression of Survivin in Oral Squamous Cell Carcinoma

• Jinbu Yoshinori

  Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University

• Tsukinoki Keiichi

  Department of Diagnostic Science, Division of Pathology, Kanagawa Dental College

• Miyagi Norito

  Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University

• Senna Tomohiro

  Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University

• Obi Yuri

  Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University

• Matsumoto Koichi

  Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University

• Noguchi Tadahide

  Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University

• Kusama Mikio

  Department of Dentistry, Oral and Maxillofacial Surgery, Jichi Medical University

抄録

Survivin is a new and structurally unique member of the inhibitor of apoptosis family, expressed in all of the most common human cancers. We performed immunohistochemical staining of survivin and analyzed the relation with the clinicopathologic characteristics in human oral cancers. Oral biopsy specimens of 19 cases (12 men and 7 women) of oral cancer were used. The overall survivin positivity was 58%. The percentage of survivin-positive specimens in the T1+T2 group was significantly higher than that in the T3+T4 group (P=0.024) and the percentage of survivin-positive specimens in the N0 group was also significantly higher than that in the N+group (P=0.027). A slightly higher percentage of survivin-positive specimens was observed in the gingival cancer group compared with the tongue cancer group (P=0.059) and the percentage of survivin-positive specimens in the CR+PR group was also slightly higher than that in the NC group (P=0.06). Survivin was preferentially expressed in non-advanced, non-metastatic, and chemotherapy-sensitive oral squamous cell carcinoma.

収録刊行物

• Ｏｒａｌ　Ｍｅｄｉｃｉｎｅ　＆　Ｐａｔｈｏｌｏｇｙ

  Ｏｒａｌ　Ｍｅｄｉｃｉｎｅ　＆　Ｐａｔｈｏｌｏｇｙ 11 (2), 41-44, 2006

  特定非営利活動法人 日本臨床口腔病理学会

キーワード

• survivin
• oral squamous cell carcinoma
• immunohistochemistry

詳細情報

• CRID: 1390001204470827648
• NII論文ID: 130004509485
• DOI: 10.3353/omp.11.41
• ISSN: 18821537
• ISSN: 13420984
• Web Site: https://search.jamas.or.jp/link/ui/2007231059
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可