A case report of multiple-drug-induced gingival overgrowth with TIMP-3 over-expression

• Kubota Takehiko

  Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences

• Itagaki Manami

  Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences

• Morozumi Toshiya

  Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences

• Maruyama Satoshi

  Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences

• Nakasone Naohiro

  Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences

• Shimizu Taro

  Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences

• Saku Takashi

  Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences

• Yoshie Hiromasa

  Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences

抄録

A case of multiple-drug-induced gingival overgrowth (GO) in a 46-year-old male is reported. The patient exhibited severe gingival enlargement throughout the entire mandible and maxilla with a history of multiple medications for psychiatric and internal diseases. A gingivectomy specimen was examined pathologically and further analyzed using immunohistochemical and molecular biological methods for the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Histologically, the gingival overgrowth was due to fibrous granulation tissue with hyperplastic collagen bundles and squamous epithelia, and the lesion was pathologically diagnosed as drug-induced gingival hyperplasia. An enhanced transcript level for TIMP-3 but reduced levels for MMPs and cathepsin L were quantitatively determined by RT-PCR. TIMP-3 was strongly immunohistochemically localized in fibroblasts and endothelial cells. DNA invader genotyping revealed that the patient carried one GO-related allele (α2 integrin +807C). These findings showed that, in this GO case, collagen accumulation in the gingival granulation tissue was associated with decreased MMPs and increased TIMP-3 expression, which was suggested to be synergistically induced by simultaneous and multiple medications, including nifedipine and antipsychotic drugs.

収録刊行物

• Ｏｒａｌ　Ｍｅｄｉｃｉｎｅ　＆　Ｐａｔｈｏｌｏｇｙ

  Ｏｒａｌ　Ｍｅｄｉｃｉｎｅ　＆　Ｐａｔｈｏｌｏｇｙ 12 (4), 141-148, 2008

  特定非営利活動法人 日本臨床口腔病理学会

キーワード

• gene expression
• gingival overgrowth
• multiple drugs
• metalloproteinases
• SNPs

詳細情報

• CRID: 1390001204470245760
• NII論文ID: 130004509511
• NII論文ID: 80019796592
• DOI: 10.3353/omp.12.141
• ISSN: 18821537
• ISSN: 13420984
• Web Site: https://search.jamas.or.jp/link/ui/2009119983
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可