A Case of Type C Chronic Hepatitis Developing Type 1 Diabetes Mellitus Two Years Later after Interferon Therapy with Appearance of Anti-GAD Antibody

• Kubota Ken

  Department of Endocrinology and Metabolism, Tokyo Metropolitan Komagome Hospital

• Asukata Nami

  Department of Endocrinology and Metabolism, Tokyo Metropolitan Komagome Hospital

• Katayanagi Naoko

  Department of Endocrinology and Metabolism, Tokyo Metropolitan Komagome Hospital

• Murakami Tohru

  Department of Endocrinology and Metabolism, Tokyo Metropolitan Komagome Hospital

Bibliographic Information

Other Title

• インターフェロン療法による抗GAD抗体出現の2年後に1A型糖尿病を発症したC型慢性肝炎の1例
• 症例報告 インターフェロン療法による抗GAD抗体出現の2年後に1A型糖尿病を発症したC型慢性肝炎の1例
• ショウレイ ホウコク インターフェロン リョウホウ ニ ヨル コウGAD コウタイ シュツゲン ノ 2ネンゴ ニ 1Aガタ トウニョウビョウ オ ハッショウ シタ Cガタ マンセイ カンエン ノ 1レイ

Abstract

A woman born in 1962 underwent 6 month-therapy with interferon (IFN) from July 1999 for type C chronic hepatitis. Diabetic ketoacidosis (DKA) developed in May 2002 and insulin treatment was begun. Plasma glucose level (mg/dl) was less than 110 until the end of 2001, but had been 154 four months before, 327 two weeks before, and 568 at the DKA event. She then became insulin-dependent and her daily insulin injection was increased to 52 units. As anti-GAD antibody, ICA, and IA-2 antibody were all positive, she was diagnosed as having type 1 diabetes mellitus. Anti-GAD antibody was negative before and during IFN therapy, but was 23.3 U/ml, and thus positive in January 2000 immediately after the end of therapy. It remained positive until diabetes mellitus developed. She had class II HLA antigens of DRB1^*0901, DQB1^*0302, and DQB1^*0303, which reflected the susceptibility to type 1 diabetes mellitus in the Japanese population. The present case suggests that screening for anti-GAD antibody may enable us to predict and prevent the development of type 1 diabetes in patients undergoing IFN therapy.

Journal

• Journal of the Japan Diabetes Society

  Journal of the Japan Diabetes Society 49 (10), 809-814, 2006

  THE JAPAN DIABETES SOCIETY

Keywords

• 1型糖尿病
• インターフェロン
• 抗GAD抗体
• C型慢性肝炎

Details

• CRID: 1390001204905739264
• NII Article ID: 130004510943
• NII Article ID: 10018393546
• NII Book ID: AN00166576
• DOI: 10.11213/tonyobyo.49.809
• ISSN: 1881588X
• ISSN: 0021437X
• NDL BIB ID: 8581180
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8581180
• Web Site: https://search.jamas.or.jp/link/ui/2007079056
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • CiNii Articles
• Abstract License Flag: Disallowed