Genotoxicity Evaluation of Titanium Dioxide Nanoparticles

• 江馬 眞

  独立行政法人産業技術総合研究所

• 小林 憲弘

  独立行政法人産業技術総合研究所

• 納屋 聖人

  独立行政法人産業技術総合研究所

• 花井 荘輔

  独立行政法人産業技術総合研究所

• 中西 準子

  独立行政法人産業技術総合研究所

書誌事項

タイトル別名

• ナノサイズ二酸化チタンの遺伝毒性評価

抄録

The present paper summarizes the genotoxicity of titanium dioxide（TiO₂），widely used in the production of paints paper and plastics, as food additives and colorants, and increasingly, as nanpoparticles in pharmaceutical and cosmetics products, based on data published in openly available scientific literature. Many studies have examined the genotoxicity of TiO₂ nanoparticles, using in vitro comet assays, bacterial and mammalian cell mutation tests, chromosomal aberration assays and micronucleus assays, and in vivo and ex vivo assays. Positive results were observed in tests on DNA damage, mammalian cell mutation, mammalian cell chromosome aberration, sister chromatid exchange, conventional and cytokinesis-blocked micronuclei frequency, and hprt mutation frequency. Some studies suggest that the genotoxicity of TiO₂ nanoparticles results from oxidative DNA damage. Results of studies in vivo correlated with results obtained in vitro are helpful for interpretation of the data. Genotoxicity studies with negative outcomes are also reported. A battery of standard genotoxicity testing methods covering a wide range of mechanisms is adequate to clarify the genotoxicity of TiO₂ particles.

収録刊行物

• 環境毒性学会誌

  環境毒性学会誌 12 (2), 71-84, 2009

  日本環境毒性学会

キーワード

• Titanium dioxide
• Nanoparticles
• Genotoxicity
• DNA damage
• Comet assay
• Gene mutation
• Chromosome aberration
• Micronuclei

詳細情報

• CRID: 1390282679463956224
• NII論文ID: 130004542782
• DOI: 10.11403/jset.12.71
• ISSN: 18825958
• ISSN: 13440667
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可