Why Does Filaggrin Decrease by Filaggrin Gene Mutations?: The C-Terminal Domain Riddle

• SAKABE Jun-ichi

  Depatment of dermatology, University of Occupational and Environmental Health

Bibliographic Information

Other Title

• フィラグリン遺伝子変異によってなぜフィラグリンが低下するのか：C末端領域の謎

Abstract

Profilaggrin is one of the important proteins in the skin barrier function. It has a functional region, filaggrin 37kDa, which is related to keratin intermediate filament (KIF) aggregation and natural moisturizing factor (NMF). Recently, many studies have indicated that imperfect profilaggrin proteins can be produced even from several mutated-profilaggrin genes. However, filaggrin monomers are not formed from imperfect profilaggrin. It is thus suggested that the profilaggrin C-terminal region is mandatory for the processing of profilaggrin.Skin Research, Suppl. 16: 25-28, 2011

Journal

• Hifu no kagaku

  Hifu no kagaku 10 (Suppl.16), 25-28, 2011

  Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

Keywords

• profilaggrin
• filaggrin
• C-terminal region
• mutation
• homology analysis

Details

• CRID: 1390282680164645504
• NII Article ID: 130004546892
• NII Article ID: 130005438670
• DOI: 10.11340/skinresearch.10.suppl.16_25
• ISSN: 18839614
• ISSN: 13471813
• Web Site: https://search.jamas.or.jp/link/ui/2012230907
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
• Abstract License Flag: Disallowed