舌疼痛を伴った口腔カンジダ症に対するイトラコナゾール内用液の臨床的検討

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  • Evaluation of clinical usefulness of itraconazole oral solution on oral treatment candidiasis accompanied with tongue pain
  • ゼツ トウツウ オ トモナッタ コウクウ カンジダショウ ニ タイスル イトラコナゾール ナイヨウエキ ノ リンショウテキ ケントウ

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We report a clinical investigation of patients who visited our hospital complaining of tongue pain and were diagnosed as oral candidiasis. Twenty-five patients were diagnosed based on the symptoms and mycological test during the 1 year and 8 month period between April 2007 and December 2008. We administered itraconazole oral solution (ITCZ-OS) to the patients for their symptoms, and used the visual analogue scale to determine the effectiveness of this treatment. Based on symptomatic evaluation, “marked improvement of tongue pain” was observed in 95.0% of the patients with acute pseudomembranous candidiasis, and 89.0% of the patients with chronic atrophic candidiasis, and “improvement” of tongue pain” was observed in 49.0% of the patients with chronic hypertrophic candidiasis. After this treatment, 88.9% of the mycological tests for acute pseudomembranous candidiasis were negative, and 100% of the patients with chronic atrophic candidiasis, and 50.0% of those for chronic hypertrophic candidiasis were negative. These results indicate that itraconazole oral solution appears to be effective in the treatment of oral candidiasis accompanied with tongue pain.

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