THERAPEUTIC EFFICACY OF PREGABALIN IN PATIENTS WITH LEG SYMPTOMS DUE TO LUMBAR SPINAL STENOSIS
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- TAKAHASHI NAOTO
- Department of Orthopaedic Surgery, Southern Tohoku General Hospital Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine
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- ARAI ITARU
- Department of Orthopaedic Surgery, Southern Tohoku General Hospital
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- KAYAMA SATORU
- Department of Orthopaedic Surgery, Southern Tohoku General Hospital
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- ICHIJI KENJI
- Department of Orthopaedic Surgery, Southern Tohoku General Hospital
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- FUKUDA HIRONARI
- Department of Orthopaedic Surgery, Southern Tohoku General Hospital Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine
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- KAGA TAKAHIRO
- Department of Orthopaedic Surgery, Southern Tohoku General Hospital Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine
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- KONNO SHIN-ICHI
- Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine
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The purpose of this study was to evaluate the therapeutic efficacy of pregabalin in patients with leg symptoms due to lumbar spinal stenosis. Study subjects were classified into two groups according to their pharmacotherapy: the pregabalin group, treated with nonsteroidal anti-inflammatory drug and pregabalin combination therapy, and the control group, treated with nonsteroidal anti-inflammatory drug monotherapy. The two groups were compared in terms of the duration of pain after the onset of leg symptoms and the type of neurogenic intermittent claudication, whether radicular-, caudal-, or mixed-type. Numerical rating scale and Roland-Morris Disability Questionnaire scores were evaluated before and 3 months after treatment. After 3 months of treatment, there were significant differences in the numerical rating scale for radicular- and mixed-types, but not for caudal-type, between the two groups in the subjects with leg symptoms for greater than 3 months. There were significant differences between the two groups in Roland-Morris Disability Questionnaire scores for mixed-type, but not for radicular- and caudal-types, in the subjects with leg symptoms for less than 3 months and for radicular- and mixed-types, but not for caudal-type, in the subjects with leg symptoms for greater than 3 months. Nonsteroidal anti-inflammatory drug and pregabalin combination therapy may be more effective than nonsteroidal anti-inflammatory drug monotherapy for the relief of leg symptoms due to lumbar spinal stenosis, preventing aggravation of subjective symptoms and improving quality of life for patients with radicular- and mixed-types in subjects with leg symptoms for greater than 3 months, although it may be necessary to consider alternative therapy for patients with caudal-type.
収録刊行物
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- 福島医学会
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福島医学会 60 (1), 35-42, 2014
福島医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206305215616
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- NII論文ID
- 130004556146
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- NII書誌ID
- AA0065246X
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- COI
- 1:STN:280:DC%2BC2cbivFeltA%3D%3D
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- ISSN
- 21854610
- 00162590
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- PubMed
- 25030722
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可