Effect of Lacto-<i>N</i>-biose I on the Antigen-specific Immune Responses of Splenocytes

• GOTO Masao

  National Agriculture and Food Research Organization National Food Research Institute

• TAKANO-ISHIKAWA Yuko

  National Agriculture and Food Research Organization National Food Research Institute

• NISHIMOTO Mamoru

  National Agriculture and Food Research Organization National Food Research Institute

• KITAOKA Motomitsu

  National Agriculture and Food Research Organization National Food Research Institute

抄録

We examined the effect of lacto-N-biose I (LNB) on Antigen (Ag)-specific responses of immune cells. LNB exposure in vitro suppressed Ag-specific Interleukin (IL)-4 secretion of mouse splenocytes significantly. However, IL-4 secretion from CD4⁺ T cells stimulated with anti-CD3ε did not changed significantly with LNB exposure. Additionally, Ag-specific Th1 cytokines did not change. Therefore LNB might suppress Ag-specific IL-4 through modification of Ag-presenting cells (APCs) in a manner independent of Th1-type immune development.<br>

収録刊行物

• Bioscience of Microbiota, Food and Health

  Bioscience of Microbiota, Food and Health 31 (2), 47-50, 2012

  BMFH出版会

キーワード

• LNB
• IL-4
• naïve immune cells
• anti-allergy

詳細情報

• CRID: 1390001205410876160
• NII論文ID: 130004562665
• NII論文ID: 10030872794
• NII書誌ID: AA12588288
• DOI: 10.12938/bmfh.31.47
• ISSN: 21863342
• Web Site: https://www.jstage.jst.go.jp/article/bmfh/31/2/31_2_47/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013046794
• 本文言語コード: en
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• 抄録ライセンスフラグ: 使用不可