関節リウマチに対するレーザー照射療法の機能ゲノム科学的考察

• 安孫子 宜光

  Department of Biochemistry and Molecular Biology, Nihon University School of Dentistry at Matsudo

書誌事項

タイトル別名

• Functional Genomic Study on Laser Therapy for Rheumatoid Arthritis

抄録

Rheumatoid arthritis (RA) is a systemic autoimmune disorder that involves inflammation and pain of joints and has been treated by steroid hormones. However, long-term use of steroid often causes side effects. Low-level laser irradiation (LLLI) is being evaluated for treating RA, and no side effects have been reported. LLLI reduced inflammation in collagen-induced RA rats. Linearly polarized infrared light irradiation (IPIL) and steroid reduced the expression of IL-8 in human RA synoviocyte MH-7A cells. GeneChip analysis coupled with a signal pathway database showed that steroid randomly altered the expression of many genes including unwanted genes, whereas IPIL reduced genes which are useful for anti-inflammation.

収録刊行物

• 日本レーザー歯学会誌

  日本レーザー歯学会誌 21 (3), 179-184, 2010

  日本レーザー歯学会

キーワード

• 関節リウマチ
• レーザー照射
• 遺伝子チップ
• 機能ゲノム科学

詳細情報

• CRID: 1390001204474718208
• NII論文ID: 130004565007
• DOI: 10.5984/jjpnsoclaserdent.21.179
• ISSN: 21856702
• ISSN: 09177450
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可