Glucose administration during volume resuscitation using dextran-40 from hemorrhagic shock ameliorates acid/base-imbalance in fasted rats under sevoflurane anesthesia
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- Kawamura Gaku
- Department of Anesthesiology, Faculty of Medicine, The University of Tokyo
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- Kitamura Takayuki
- Department of Anesthesiology, Toho University Sakura Medical Center
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- Sato Kanako
- Department of Anesthesiology, Faculty of Medicine, The University of Tokyo
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- Sato Rui
- Department of Anesthesiology, Faculty of Medicine, The University of Tokyo
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- Mori Yoshiteru
- Department of Anesthesiology, Faculty of Medicine, The University of Tokyo
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- Araki Yuko
- Department of Anesthesiology, Faculty of Medicine, The University of Tokyo
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- Yamada Yoshitsugu
- Department of Anesthesiology, Faculty of Medicine, The University of Tokyo
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抄録
The hyperglycemic response is an important prognostic factor for survival after hemorrhage. In this study, we investigated the effects of glucose administration during volume resuscitation from hemmorhagic shock in fasted rats under sevoflurane anesthesia on hemodynamics, acid/base-balance and glucose metabolism. Hemorrhagic shock was induced in rats by withdrawing 25 mL/kg of blood. For volume resuscitation, rats in groupDextran[saline] and group-Dextran[glucose] underwent infusion therapy using 10% dextran-40 dissolved in physiological saline and 10% dextran-40 dissolved in 5% glucose, respectively. Arterial blood was sampled just before blood withdrawal, immediately after blood withdrawal, immediately after volume resuscitation and at 30 min after volume resuscitation for arterial gas analyses and measurement of plasma insulin levels. After volume resuscitation, group-Dextran[glucose] showed similar arterial blood pressure, significantly lower heart rate, similar arterial PO2 and similar hematocrit in comparison with group-Dextran[saline], suggesting that there was no particular difference in oxygen demand/supply-balance between the two groups. After volume resuscitation, group-Dextran[glucose] showed significantly higher arterial pH, similar arterial PCO2, significantly higher bicarbonate levels and significantly higher base excess in comparison with group-Dextran[saline], suggesting that metabolic acidosis is a cause of the difference in acid/base-balance between the two groups. After volume resuscitation, group-Dextran[glucose] showed significantly higher glucose levels, significantly higher insulin levels and significantly lower lactate levels in comparison with group-Dextran[saline]. At 30 min after volume resuscitation, base excess correlated significantly with lactate levels. These results suggest that glucose administration during volume resuscitation using dextran-40 from hemorrhagic shock ameliorates acid/base-imbalance associated with hyperlactatemia in fasted rats under sevoflurane anesthesia.
収録刊行物
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- BioScience Trends
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BioScience Trends 7 (3), 138-143, 2013
特定非営利活動法人 バイオ＆ソーシャル・サイエンス推進国際研究交流会