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- CHEN Huayue
- Department of Anatomy, Gifu University School of Medicine
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- HAYAKAWA Daisuke
- Department of Anatomy, Gifu University School of Medicine
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- EMURA Shoichi
- Nursing Course, Gifu University School of Medicine
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- OZAWA Yuki
- Department of Anatomy, Gifu University School of Medicine
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- TAGUCHI Hirotaka
- Department of Anatomy, Gifu University School of Medicine
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- YANO Ryuichiro
- Department of Anatomy, Gifu University School of Medicine
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- SHOUMURA Shizuko
- Department of Anatomy, Gifu University School of Medicine
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抄録
Young female rats were fed with normal (1.18%) or low (0.05%) calcium diet for 3,7,15 or 30 days. The morphology of the parathyroid glands was studied together with serum calcium, parathyroid hormone (PTH), calcitonin and bone mineral density (BMD). As compared to the animals fed with the normal calcium diet, BMD of whole body of the rats fed with the low calcium diet was significantly decreased, whereas the serum PTH level was increased. The parathyroid glands in the rats fed with the low calcium diet were markedly enlarged. In the parathyroid chief cells of the rats fed with the low calcium diet, the Golgi complexes and the cisternae of the granular endoplasmic reticulum were well developed, while the large granules and large vacuolar bodies decreased. Some secretory granules located near the plasma membrane. A proportionally larger increase of the cytoplasm was estimated in the rats fed with the low calcium diet for three and seven days. Enlargement of the cytoplasm and rather frequent mitoses of the chief cells were observed in the rats fed with the low calcium diet for 15 and 30 days. These findings suggest that the rapid bone loss in young rats induced by the low calcium diet is essentially due to stimulated activity of the parathyroid gland. The stimulated gland may be a result of hypertrophy at the early stage and a combination of hypertrophy and hyperplasia at the later stage of calcium deficiency.
収録刊行物
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- Okajimas Folia Anatomica Japonica
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Okajimas Folia Anatomica Japonica 78 (5), 153-159, 2001
Editorial Board of Okajimas Folia Anatomica Japonica
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詳細情報 詳細情報について
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- CRID
- 1390282680436680192
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- NII論文ID
- 130004650569
- 80015154044
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- COI
- 1:CAS:528:DC%2BD38XjslSqs7g%3D
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- ISSN
- 0030154X
- http://id.crossref.org/issn/0030154X
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可