Isoflurane Preconditioning Ameliorates Renal Ischemia-Reperfusion Injury through Antiinflammatory and Antiapoptotic Actions in Rats
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- Liang Yaoxian
- Department of Nephrology, Peking University Third Hospital
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- Li Zhengqian
- Department of Anesthesiology, Peking University Third Hospital
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- Mo Na
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
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- Li Min
- Department of Anesthesiology, Peking University Third Hospital
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- Zhuang Zhen
- Department of Nephrology, Peking University Third Hospital
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- Wang Jun
- Department of Anesthesiology, Peking University Third Hospital
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- Wang Yue
- Department of Nephrology, Peking University Third Hospital
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- Guo Xiangyang
- Department of Anesthesiology, Peking University Third Hospital
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抄録
Renal ischemia-reperfusion (I/R) injury is a major cause of acute kidney injury via inflammation and cell apoptosis. Volatile anesthetics have been shown to exert organ-protective effects against kidney damage in vivo and in vitro. In the present study, we investigated the effects of isoflurane, a commonly used volatile anesthetic, on renal I/R injury and the underlying mechanisms. Rats subjected to renal I/R displayed higher serum creatinine and blood urea nitrogen levels than sham rats as well as severe histopathological damage. Renal I/R also resulted in a nuclear factor-κB (NF-κB)-mediated inflammatory response and dysfunction of the p53-Bax-caspase-3 apoptotic pathway. Rats preconditioned with 1.5% isoflurane for 2 h had better renal function and less tubular apoptosis 24 h after I/R injury than control rats. Pretreatment with isoflurane suppressed renal NF-κB activation, leading to a reduction in proinflammatory molecules (high-mobility group box 1, interleukin-1β, and tumor necrosis factor-α) both in the kidneys and circulation. In addition, rats subjected to isoflurane preconditioning had a higher Bcl-2/Bax ratio and less cleaved caspase-3. Our findings suggest that preconditioning with a clinically relevant concentration of isoflurane attenuates renal I/R injury, based at least in part on its ability to modulate renal inflammation and apoptosis.
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 37 (10), 1599-1605, 2014
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282679609276416
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- NII論文ID
- 130004677548
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- NII書誌ID
- AA10885497
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- COI
- 1:STN:280:DC%2BC2cbotlOqsA%3D%3D
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 025838702
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- PubMed
- 25088045
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可