Similarity of GATA-3 expression between rat and human mammary gland

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  • Kinoshita Yuichi
    Department of Pathology II, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, Japan Division of Pathology, Kansai Medical University Takii Hospital, 10-15 Fumizono, Moriguchi, Osaka 570-8507, Japan
  • Yoshizawa Katsuhiko
    Department of Pathology II, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, Japan
  • Emoto Yuko
    Department of Pathology II, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, Japan
  • Yuki Michiko
    Department of Pathology II, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, Japan
  • Yuri Takashi
    Department of Pathology II, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, Japan
  • Shikata Nobuaki
    Division of Pathology, Kansai Medical University Takii Hospital, 10-15 Fumizono, Moriguchi, Osaka 570-8507, Japan
  • Tsubura Airo
    Department of Pathology II, Kansai Medical University, 2-5-1 Shin-machi, Hirakata, Osaka 573-1010, Japan

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  • Similarity of GATA-3 Expression between Rat and Human Mammary Glands

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The GATA family members are zinc finger transcription factors involved in cell differentiation and proliferation. In particular, GATA-3 is necessary for mammary gland maturation and is a useful marker in the characterization of mammary carcinoma in humans. The expression of GATA-3 protein in normal mammary glands, fibroadenomas and carcinomas was immunohistochemically compared in female rats and humans. In normal mammary glands of rats and humans, scattered luminal cells in the acini and whole ductal epithelial cells were positive for GATA-3 in the nuclei. No positive cells were detected in rat or human fibroadenomas. In rat and human mammary carcinomas, the nuclei of proliferating luminal-derived cancer cells expressed GATA-3. Therefore, GATA-3 protein is a candidate marker for mammary carcinoma in rats as well as humans.

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