Histological dermal changes caused by preparation and application procedures in percutaneous dose toxicity studies in dogs, rabbits and rats
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- Mitsuishi Mikio
- Kumamoto Laboratory, Nonclinical Research Center, LSI Medience Corporation, 1285 Kurisaki-machi, Uto-shi, Kumamoto 869-0425, Japan
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- Oshikata Takafumi
- Kumamoto Laboratory, Nonclinical Research Center, LSI Medience Corporation, 1285 Kurisaki-machi, Uto-shi, Kumamoto 869-0425, Japan
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- Kumabe Shino
- Kashima Laboratory, Nonclinical Research Center, LSI Medience Corporation, 14-1 Sunayama, Kamisu-shi, Ibaraki 314-0255, Japan
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- Kobayashi Azusa
- Kumamoto Laboratory, Nonclinical Research Center, LSI Medience Corporation, 1285 Kurisaki-machi, Uto-shi, Kumamoto 869-0425, Japan
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- Katoku Koshiro
- Kumamoto Laboratory, Nonclinical Research Center, LSI Medience Corporation, 1285 Kurisaki-machi, Uto-shi, Kumamoto 869-0425, Japan
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- Kanno Takeshi
- Kumamoto Laboratory, Nonclinical Research Center, LSI Medience Corporation, 1285 Kurisaki-machi, Uto-shi, Kumamoto 869-0425, Japan
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- Hamamura Masao
- Kumamoto Laboratory, Nonclinical Research Center, LSI Medience Corporation, 1285 Kurisaki-machi, Uto-shi, Kumamoto 869-0425, Japan
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- Tsuchitani Minoru
- Kashima Laboratory, Nonclinical Research Center, LSI Medience Corporation, 14-1 Sunayama, Kamisu-shi, Ibaraki 314-0255, Japan
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抄録
We reevaluated histological slides of dorsal skin in control animals from past percutaneous dose toxicity studies using dogs, rabbits and rats to provide background data concerning histological changes related to preparation and application procedures and vehicles or embrocations of every variety. Acanthosis, dermal or perifollicular inflammatory cell infiltration in dogs; hyperkeratosis, acanthosis, dermal inflammatory cell infiltration or hemorrhage in rabbits; and acanthosis, dermal inflammatory cell infiltration, crust or foreign body granuloma in rats were present as procedure-related underlying histological changes in the control animals. Four mechanical acts, (1) rubbing with gauze to remove an administered substance for reapplication, (2) use of a taut bandage to avoid slipping from the application site, (3) peeling a patch off as a preparation procedure for reapplication, and (4) clipping or shaving, were considered to cause injury to the skin. The degree of influence of the various application procedures was found to be as follows: sham, lotion < cream < ointment and tape in dogs; untreated control, sham < lotion < tape and poultice in rabbits; and sham, sodium carboxymethylcellulose < olive oil and lotion < ointment and tape in rats. The degree of ointment influence on rabbits is equivocal.
収録刊行物
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- Journal of Toxicologic Pathology
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Journal of Toxicologic Pathology 28 (1), 1-9, 2015
日本毒性病理学会
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詳細情報 詳細情報について
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- CRID
- 1390282679393220864
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- NII論文ID
- 130004677740
- 40020360951
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- NII書誌ID
- AN10232280
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- ISSN
- 1881915X
- 09149198
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- NDL書誌ID
- 026103110
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可