Characteristics and Pharmacological Regulation of Epithelial Na⁺ Channel (ENaC) and Epithelial Na⁺ Transport

DOI Web Site Web Site PubMed 被引用文献10件 参考文献144件
  • Marunaka Yoshinori
    Departments of Molecular Cell Physiology and Bio-Ionomics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan Japan Institute for Food Education and Health, St. Agnes’ University, Japan

書誌事項

タイトル別名
  • Characteristics and Pharmacological Regulation of Epithelial Na<sup>+</sup> Channel (ENaC) and Epithelial Na<sup>+</sup> Transport

この論文をさがす

抄録

Epithelial Na+ transport participates in control of various body functions and conditions: e.g., homeostasis of body fluid content influencing blood pressure, control of amounts of fluids covering the apical surface of alveolar epithelial cells at appropriate levels for normal gas exchange, and prevention of bacterial/viral infection. Epithelial Na+ transport via the transcellular pathway is mediated by the entry step of Na+ across the apical membrane via Epithelial Na+ Channel (ENaC) located at the apical membrane, and the extrusion step of Na+ across the basolateral membrane via the Na+,K+-ATPase located at the basolateral membrane. The rate-limiting step of the epithelial Na+ transport via the transcellular pathway is generally recognized to be the entry step of Na+ across the apical membrane via ENaC. Thus, up-/down-regulation of ENaC essentially participates in regulatory systems of blood pressure and normal gas exchange. Amount of ENaC-mediated Na+ transport is determined by the number of ENaCs located at the apical membrane, activity (open probability) of individual ENaC located at the apical membrane, single channel conductance of ENaC located at the apical membrane, and driving force for the Na+ entry via ENaCs across the apical membrane. In the present review article, I discuss the characteristics of ENaC and how these factors are regulated.

収録刊行物

被引用文献 (10)*注記

もっと見る

参考文献 (144)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ