Identification and Characterization of Vancomycin-resistant Enterococcus species Frequently Isolated from Laboratory Mice
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- Yamanaka Hitoki
- Division of Comparative Medicine, Center for Frontier Life Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan
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- Takagi Toshikazu
- Division of Comparative Medicine, Center for Frontier Life Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan
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- Ohsawa Makiko
- Division of Comparative Medicine, Center for Frontier Life Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan
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- Yamamoto Naoto
- Division of Comparative Medicine, Center for Frontier Life Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan
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- Kubo Noriaki
- Division of Comparative Medicine, Center for Frontier Life Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan
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- Takemoto Takahira
- Division of Comparative Medicine, Center for Frontier Life Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan
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- Sasano Shoko
- Division of Comparative Medicine, Center for Frontier Life Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan
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- Masuyama Ritsuko
- Department of Molecular Bone Biology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8588, Japan
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- Ohsawa Kazutaka
- Division of Comparative Medicine, Center for Frontier Life Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan
書誌事項
- タイトル別名
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- Identification and Characterization ofVancomycin-resistant <i>Enterococcus</i> species Frequently Isolated from Laboratory Mice
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抄録
To determine the prevalence of drug resistant bacteria colonizing laboratory mice, we isolated and characterized vancomycin-resistant Enterococcus species (VRE) from commercially available mice. A total of 24 VRE isolates were obtained from 19 of 21 mouse strains supplied by 4 commercial breeding companies. Of these, 19 isolates of E. gallinarum and 5 isolates of E. casseliflavus possessing the vanC1 and vanC2/3 genes intrinsically, exhibited intermediate resistance to vancomycin respectively. In addition, these isolates also exhibited diverse resistant patterns to erythromycin, tetracycline, and ciprofloxacin, whereas the use of antibiotics had not been undertaken in mouse strains tested in this study. Although 6 virulence-associated genes (ace, asa, cylA, efaA, esp, and gelE) and secretion of gelatinase and hemolysin were not detected in all isolates, 23 of 24 isolates including the isolates of E. casselifalvus secreted ATP into culture supernatants. Since secretion of ATP by bacteria resident in the intestinal tract modulates the local immune responses, the prevalence of ATP-secreting VRE in mice therefore needs to be considered in animal experiments that alter the gut microflora by use of antibiotics.
収録刊行物
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- Experimental Animals
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Experimental Animals 63 (3), 297-304, 2014
公益社団法人 日本実験動物学会
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詳細情報 詳細情報について
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- CRID
- 1390001205045240320
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- NII論文ID
- 130004677820
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- NII書誌ID
- AA11032321
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- COI
- 1:STN:280:DC%2BC2cbnvVGrtw%3D%3D
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- ISSN
- 18817122
- 00075124
- 13411357
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- HANDLE
- 10069/34747
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- NDL書誌ID
- 025599157
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- PubMed
- 25077759
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 使用不可