A Fluorescence Probe Based on Biomolecule-stabilized Gold Nanoclusters for the Detection of Pazufloxacin Mesilate

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  • CAO Xueling
    State Key Laboratory of Supramolecular Structure and Materials, Jilin University Department of Chemistry, Jilin Institute of Chemical Technology
  • LIAN Lili
    State Key Laboratory of Supramolecular Structure and Materials, Jilin University Department of Chemistry, Jilin Institute of Chemical Technology
  • LI Hongwei
    State Key Laboratory of Supramolecular Structure and Materials, Jilin University
  • WU Yuqing
    State Key Laboratory of Supramolecular Structure and Materials, Jilin University
  • LOU Dawei
    Department of Chemistry, Jilin Institute of Chemical Technology

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抄録

In the present study, biomolecule-stabilized Au nanoclusters were demonstrated as a novel fluorescence probe for sensitive and selective detection of pazufloxacin mesilate (PZFX) for the first time. The linear decrease in the fluorescence intensity of Au nanoclusters induced by PZFX allowed for the quantitative detection of PZFX in the range of 0.15 μg/mL to 1 mg/mL, and the detection limit for PZFX was 0.2 μg/mL. Circular dichroism spectroscopy and fluorescence decay studies were then performed to discuss the quenching mechanism. In addition, practical application of the present approach was also demonstrated for real samples, which suggested its great potential for accurate analysis of similar drugs.

収録刊行物

  • Analytical Sciences

    Analytical Sciences 30 (8), 817-822, 2014

    社団法人 日本分析化学会

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