Pilot Study on Interferon-γ-producing T Cell Subsets after the Protective Vaccination with Radiation-attenuated Cercaria of Schistosoma japonicum in the Miniature Pig Model

DOI 機関リポジトリ HANDLE PubMed 参考文献29件
  • Abdel-Hafeez Ekhlas Hamed
    Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University Department of Parasitology, Faculty of Medicine, Minia University
  • Watanabe Kanji
    Department of Parasitology, Institute of Tropical Medicine (NEKKEN), Nagasaki University
  • Kamei Kaori
    Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University
  • Kikuchi Mihoko
    Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University
  • Chen Honggen
    Jiangxi Provintial Institute of Parasitic Diseases
  • Daniel Boamah
    Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University
  • Yu Chuanxin
    Jiangsu Institute of Parasitic Diseases
  • Hirayama Kenji
    Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University

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  • Pilot Study on Interferon-γ-producing T Cell Subsets after the Protective Vaccination with Radiation-attenuated Cercaria of <i>Schistosoma japonicum</i> in the Miniature Pig Model

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CLAWN miniature pig has been shown to serve as a suitable host for the experimental infection of Schistosoma japonicum. In this study, we found that radiation-attenuated cercaria (RAC) vaccine gave CLAWN miniature pigs protective immunity against subsequent challenge infection with S. japonicum cercaria. To characterize the protective immune response of the pig model vaccinated by attenuated cercaria, flow cytometric analysis of the reactive T cell subsets was performed. The intracellular interferon (IFN)-γ and the cell surface markers revealed the peripheral blood CD3+ T-lymphocytes produced significant amounts of IFN-γ during the immunization period and after the challenge infection. CD4+ αβ-T cells as well as CD4+/CD8αmid double positive and/or CD8αhigh αβ-T cells were the major IFN-γ-producing CD3+ T cells. On the contrary, γδ T cells did not produce intracellular IFN-γ. Our results suggested that RAC-vaccinated miniature pigs showed effective protective immunity through the activation of αβ T cells bearing antigen specific T-cell receptors but not through the activation of γδ T cells.

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