Crystalglobulinemia with Fulminant Course with Cylinder-like Bodies on Peripheral Blood Smear
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- Kawaguchi Takeshi
- Department of Rheumatology, Infectious Diseases, and Laboratory Medicine, Faculty of Medicine, University of Miyazaki, Japan
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- Kariya Yumi
- Department of Rheumatology, Infectious Diseases, and Laboratory Medicine, Faculty of Medicine, University of Miyazaki, Japan
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- Matsuda Motohiro
- Department of Rheumatology, Infectious Diseases, and Laboratory Medicine, Faculty of Medicine, University of Miyazaki, Japan
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- Kubo Kazuyoshi
- Department of Rheumatology, Infectious Diseases, and Laboratory Medicine, Faculty of Medicine, University of Miyazaki, Japan
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- Miyauchi Syunichi
- Department of Rheumatology, Infectious Diseases, and Laboratory Medicine, Faculty of Medicine, University of Miyazaki, Japan
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- Kusumoto Norio
- Department of Rheumatology, Infectious Diseases, and Laboratory Medicine, Faculty of Medicine, University of Miyazaki, Japan
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- Ueno Shiro
- Department of Rheumatology, Infectious Diseases, and Laboratory Medicine, Faculty of Medicine, University of Miyazaki, Japan
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- Takajo Ichiro
- Department of Rheumatology, Infectious Diseases, and Laboratory Medicine, Faculty of Medicine, University of Miyazaki, Japan
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- Nagatomo Yasuhiro
- Department of Rheumatology, Infectious Diseases, and Laboratory Medicine, Faculty of Medicine, University of Miyazaki, Japan
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- Tahira Yuki
- Section of Oncopathology and Regenerative Biology, Faculty of Medicine, University of Miyazaki, Japan
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- Yamamoto Syoko
- Section of Oncopathology and Regenerative Biology, Faculty of Medicine, University of Miyazaki, Japan
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- Yorita Kenji
- Section of Oncopathology and Regenerative Biology, Faculty of Medicine, University of Miyazaki, Japan
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- Kataoka Hiroaki
- Section of Oncopathology and Regenerative Biology, Faculty of Medicine, University of Miyazaki, Japan
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- Okayama Akihiko
- Department of Rheumatology, Infectious Diseases, and Laboratory Medicine, Faculty of Medicine, University of Miyazaki, Japan
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抄録
A 63-year-old woman presented to our hospital with fever, purpura and pain in both legs and died 4 days after admission. Her blood smear and skin biopsy showed cylinder-like bodies (20×120 μm). She was diagnosed to have monoclonal gammopathy (IgG, lambda type). An autopsy revealed cylinder-like bodies in the vasculature of various organs. We noted a proliferation of atypical plasma cells in her bone marrow, suggesting pre-existing myeloma. Crystalglobulinemia is a rare manifestation of hypergammaglobulinemia that can cause multiple embolisms of the small vessels, and this resulted in the patient's fulminant course. The identification of cylinder-like bodies in the peripheral blood may help in reaching a diagnosis in such cases.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 53 (16), 1847-1851, 2014
一般社団法人 日本内科学会