Insight into the Mechanism of Reproductive Dysfunction Caused by Neonicotinoid Pesticides

• Hoshi Nobuhiko

  Laboratory of Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University

• Hirano Tetsushi

  Laboratory of Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University

• Omotehara Takuya

  Laboratory of Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University

• Tokumoto Junko

  Laboratory of Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University

• Umemura Yuria

  Laboratory of Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University

• Mantani Youhei

  Laboratory of Histophysiology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University

• Tanida Takashi

  Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine

• Warita Katsuhiko

  Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University

• Tabuchi Yoshiaki

  Division of Molecular Genetics Research, 
Life Science Research Center, University of Toyama

• Yokoyama Toshifumi

  Laboratory of Molecular Morphology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University

• Kitagawa Hiroshi

  Laboratory of Histophysiology, Department of Animal Science, Graduate School of Agricultural Science, Kobe University

抄録

Neonicotinoids, which were developed in the 1990 s as an insecticide having selective toxicity, were later found to cause reproductive abnormalities in experimental animals. In Japan there is an attempt to preserve endangered animals, including the Japanese crested ibis, and there is a question of whether neonicotinoids affect the reproduction of this bird, since they are used in its habitat. Hence, we investigated whether the daily oral administration of the neonicotinoid clothianidin (CTD) has any deleterious effects on the reproductive function of mature male only or both young male and female quails as experimental animals. Vacuolization and the number of germ cells having fragmented DNA in seminiferous tubules, as well as the number and size of vacuoles in hepatocytes, increased dose-dependently. The ovaries showed abnormal histology in the granulosa cells, which produce progesterone. There were significant differences in egg-laying rates and embryo weights between the groups. Glutathione Peroxidase 4 (GPx4) and Manganese Superoxide Dismutase (Mn-SOD), which protect the organism from oxidative damage, showed a dose-dependent decrease. Thus, it is possible neonicotinoids affect the bird’s reproductive system through oxidative stress, reflecting an imbalance between the production of reactive oxygen species (ROS) and a biological system’s ability to readily detoxify the reactive intermediates or easily repair the resulting damage. Responding to our study, Sado Island has since succeeded in breeding Japanese crested ibis in the wild without the use of neonicotinoids.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 37 (9), 1439-1443, 2014

  公益社団法人 日本薬学会

キーワード

• neonicotinoid
• clothianidin
• oxidative stress
• reproductive dysfunction
• bird
• Japanese crested ibis

詳細情報

• CRID: 1390282679610465664
• NII論文ID: 130004684796
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.b14-00359
• COI: 1:STN:280:DC%2BC2M%2FmvFKhsA%3D%3D
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 025736757
• PubMed: 25177026
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025736757
• Web Site: https://www.jstage.jst.go.jp/article/bpb/37/9/37_b14-00359/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2015190626
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可