Sarcomatoid carcinoma of the kidney in a MEN1 patient: Case report and genetic profile
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- Cavalli Tiziana
- Department of Surgery and Translational Medicine, University of Florence, Florence, Italy
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- Giudici Francesco
- Department of Surgery and Translational Medicine, University of Florence, Florence, Italy
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- Nesi Gabriella
- Department of Surgery and Translational Medicine, University of Florence, Florence, Italy
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- Marini Francesca
- Department of Surgery and Translational Medicine, University of Florence, Florence, Italy
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- Giusti Francesca
- Department of Surgery and Translational Medicine, University of Florence, Florence, Italy
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- Cavalli Loredana
- Department of Surgery and Translational Medicine, University of Florence, Florence, Italy
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- Brandi Maria Luisa
- Department of Surgery and Translational Medicine, University of Florence, Florence, Italy
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- Tonelli Francesco
- Department of Surgery and Translational Medicine, University of Florence, Florence, Italy
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抄録
Renal tumors are exceedingly rare in Multiple Endocrine Neoplasia type 1 (MEN1), a pleyotropic hereditary cancer disorder affecting the endocrine system. Herein we report a unique case of renal sarcomatoid carcinoma with concomitant ipsilateral non-secreting adrenal adenoma occurring in a young male MEN1 patient, previously operated for hyperparathyroidism and multiple pancreatic neuroendocrine neoplasms. Molecular analysis in the MEN1 locus at 11q13 showed loss of heterozygosity in the adrenal lesion, while kidney cancer was unrelated to MEN1 syndrome.
収録刊行物
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- Endocrine Journal
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Endocrine Journal 61 (8), 781-787, 2014
一般社団法人 日本内分泌学会