Clinical Manifestations of Children with Microbiologically Confirmed Pertussis Infection and Antimicrobial Susceptibility of Isolated Strains in a Regional Hospital in Japan, 2008^|^ndash;2012
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- Horiba Kazuhiro
- Department of Pediatrics, Konan Kosei Hospital
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- Nishimura Naoko
- Department of Pediatrics, Konan Kosei Hospital
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- Gotoh Kensei
- Department of Pediatrics, Konan Kosei Hospital
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- Kawaguchi Masahiro
- Department of Pediatrics, Konan Kosei Hospital
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- Takeuchi Suguru
- Department of Pediatrics, Konan Kosei Hospital
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- Hattori Fumihiko
- Department of Pediatrics, Konan Kosei Hospital
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- Isaji Mai
- Department of Pediatrics, Konan Kosei Hospital
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- Okai Yu
- Department of Pediatrics, Konan Kosei Hospital
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- Hosono Haruki
- Department of Pediatrics, Konan Kosei Hospital
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- Takemoto Koji
- Department of Pediatrics, Konan Kosei Hospital
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- Ozaki Takao
- Department of Pediatrics, Konan Kosei Hospital
書誌事項
- タイトル別名
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- Clinical Manifestations of Children with Microbiologically Confirmed Pertussis Infection and Antimicrobial Susceptibility of Isolated Strains in a Regional Hospital in Japan, 2008–2012
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We conducted a retrospective study in 57 children (median age, 3.5 years; range, 1 month–14.5 years) with microbiologically confirmed pertussis infection over a recent 4-year period in a regional hospital in Japan. We obtained nasal swabs from all patients for Bordetella pertussis isolation as well as performed B. pertussis DNA detection using loop-mediated isothermal amplification (LAMP). Of the 57 cases, 34 (60%) were culture-positive and 57 (100%) were LAMP-positive. The frequency of each symptom was as follows: typical paroxysmal cough for over 14 days, 96% (55/57); paroxysms, 86% (49/57); posttussive vomiting, 33% (19/57); inspiratory whoop, 25% (14/57); and apnea, 12% (7/57). Hospitalization was required in 14 cases (25%), 93% (13/14) of which were aged <1 year. The proportion of patients previously immunized against diphtheria-tetanus-acellular pertussis vaccine (DTaP) was 19% (4/21) in children aged <1 year and 92% (11/12) in children aged ≥10 years. Minimum inhibitory concentrations for 6 antimicrobials (erythromycin, clarithromycin, azithromycin, minocycline, amoxicillin, and sulfamethoxazole/trimethoprim) were measured for 30 isolated strains, and all strains were susceptible to all aforementioned antimicrobials. Thus, an additional pertussis vaccination in older children is necessary, and the current macrolides-based treatment strategy is considered reasonable.
収録刊行物
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- Japanese Journal of Infectious Diseases
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Japanese Journal of Infectious Diseases 67 (5), 345-348, 2014
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会
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詳細情報 詳細情報について
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- CRID
- 1390282681216330112
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- NII論文ID
- 130004692232
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- NII書誌ID
- AA1132885X
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- ISSN
- 18842836
- 13446304
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- NDL書誌ID
- 025805217
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- PubMed
- 25241683
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可