Etiology of Acute Conjunctivitis Due to Coxsackievirus A24 Variant, Human Adenovirus, Herpes Simplex Virus, and Chlamydia in Beijing, China

DOI Web Site PubMed 参考文献25件
  • Li Jie
    Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control
  • Yang Yongsheng
    Optic Nerve Department, Eye Hospital of China Academy of Chinese Medical Sciences
  • Lin Changying
    Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control
  • Li Weihong
    Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control
  • Yang Yang
    Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control
  • Zhang Yong
    Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention
  • Jia Lei
    Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control
  • Li Xitai
    Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control
  • Chen Lijuan
    Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control
  • Wang Quanyi
    Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control

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Acute conjunctivitis is a common disease associated with high morbidity and economic burden. To clarify the etiological characteristics of acute conjunctivitis in Beijing, surveillance of acute conjunctivitis was conducted from July to October during 2007–2012 by collecting eye swabs from patients treated at surveillance hospitals affiliated with a surveillance program of 18 districts Center for Disease Prevention and Control in Beijing. Coxsackievirus A24 variant (CA24v), enterovirus 70 (EV70), human adenovirus (HAdV), herpes simplex virus (HSV), and chlamydia were identified by PCR. Phylogenetic analysis of the VP1 region of CA24v was conducted. Comparisons of proportions and statistical significance were performed using the chi-square test. HAdV was found to be the most prevalent pathogen, followed by CA24v, chlamydia, and HSV. Significant differences in the symptoms of ocular pain, photophobia, and epiphora were identified among the 4 agents. The prevalence of HAdV- and CA24v-mediated conjunctivitis peaked in July or August and September or October, respectively. Nucleotide sequences of the VP1 regions among the isolated CA24v strains shared 92.8%–100% homology. In conclusion, HAdV followed by CA24v, chlamydia, and HSV were the most common causative agents of acute conjunctivitis in Beijing. Comprehensive, continuous surveillance and advanced laboratory techniques are needed for further studies.

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