A Novel Selenadiazole Derivative Induces Apoptosis in Human Glioma Cells by Dephosphorylation of AKT
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- Zhang Yikai
- Guangdong Province Key Laboratory of Molecule Immunology and Antibody Engineering, Department of Pathology, Jinan University
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- Zheng Shanyuan
- School of Life Sciences and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong
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- Ngai Sai-Ming
- School of Life Sciences and State Key Laboratory of Agrobiotechnology, The Chinese University of Hong Kong
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- Zheng Wenjie
- Department of Chemistry, Jinan University
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- Li Jinying
- Guangdong Province Key Laboratory of Molecule Immunology and Antibody Engineering, Department of Pathology, Jinan University
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- Chen Tianfeng
- Department of Chemistry, Jinan University
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- Zhong Xueyun
- Guangdong Province Key Laboratory of Molecule Immunology and Antibody Engineering, Department of Pathology, Jinan University
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抄録
Selenadiazole derivatives are synthetic organoselenium compounds with improved anticancer activity and greater selectivity than inorganic selenium. In this study, 4-(benzo[c][1,2,5]selenadiazol-6-yl)-benzene-1,2-diamine (BSBD) was shown to induce time- and dose-dependent apoptosis in SWO-38 human glioma cells by accumulation of a sub-G1 cell population, DNA fragmentation, nuclear condensation, caspase activation and poly(ADP-ribose) polymerase (PARP) cleavage. Further mechanistic investigation showed that BSBD treatment induced dephosphorylation of AKT and DNA damage-mediated activation of p53, leading to extensive apoptosis through the mitochondrial pathway. Our findings suggest that BSBD represents a potential human glioma therapeutic.
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 62 (10), 994-999, 2014
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204178388992
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- NII論文ID
- 130004693778
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- NII書誌ID
- AA00602100
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- COI
- 1:STN:280:DC%2BC2M7ms1ShsA%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 025838640
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- PubMed
- 25273058
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可