Purple grape juice supplementation in smokers and antioxidant status according to different types of GST polymorphisms

• Cho Mi-Ran

  Department of Food & Nutrition, Daedeok Valley Campus, Hannam University

• Han Jeong-Hwa

  Department of Food & Nutrition, Daedeok Valley Campus, Hannam University

• Lee Hye-Jin

  Department of Food & Nutrition, Daedeok Valley Campus, Hannam University

• Park Yoo Kyoung

  Department of Medical Nutrition, Graduate School of East-West Medicine, Kyung Hee University

• Kang Myung-Hee

  Department of Food & Nutrition, Daedeok Valley Campus, Hannam University

書誌事項

タイトル別名

• Purple grape juice supplementation in smokers and antioxidant status according to different types of <i>GST </i>polymorphisms
• Mitochondrial reactive oxygen species accelerate the expression of heme carrier protein 1 and enhance photodynamic cancer therapy effect

抄録

DNA damages and antioxidant status was assessed after 8 weeks of purple grape juice supplementation in male smokers depending on the glutathione S-transferase polymorphisms. Ninety-five smokers consumed 480 ml of purple grape juice for 8 weeks. The blood samples were collected before and after supplementation to measure lymphocyte DNA damages, plasma antioxidants, conjugated diene, and the erythrocyte antioxidant enzymes. The diastolic pressure, lymphocyte DNA damage, and plasma conjugated diene were significantly decreased but the plasma γ-tocopherol was increased in GSTM1-null genotype, while increased blood glutathione and decreased lymphocyte DNA damage were observed in GSTM1-present genotype. In case of GSTT1 on the other hand, the decrease in diastolic pressure and lymphocyte DNA damage was observed in both null types and present types, but the erythrocyte catalase activity was decreased in GSTT1-null type and the plasma vitamin C level was increased in GSTT1-present type, suggesting that, the antioxidant effect of grape juice was greater in GSTT1-present type compared to GSTT1-null type. The intakes of 8-week purple grape juice affected diastolic blood pressures, DNA damage reductions and antioxidant status in smokers, mainly greater in GSTM1-null type and GSTT1-present type.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　Ｂｉｏｃｈｅｍｉｓｔｒｙ　ａｎｄ　Ｎｕｔｒｉｔｉｏｎ 56 (1), 49-56, 2015

  一般社団法人　日本酸化ストレス学会

キーワード

• purple grape juice
• antioxidant status
• blood pressure
• DNA damage
• <i>GST</i> polymorphism

詳細情報

• CRID: 1390282679648691456
• NII論文ID: 130004694544
• DOI: 10.3164/jcbn.14-1
• ISSN: 18805086
• ISSN: 09120009
• Web Site: https://search.jamas.or.jp/link/ui/2016045654
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可