Time-Dependent Effects of L-Tryptophan Administration on Urinary Excretion of L-Tryptophan Metabolites
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- HIRATSUKA Chiaki
- Department of Nutrition, School of Human Culture, The University of Shiga Prefecture
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- SANO Mitsue
- Department of Nutrition, School of Human Culture, The University of Shiga Prefecture
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- FUKUWATARI Tsutomu
- Department of Nutrition, School of Human Culture, The University of Shiga Prefecture
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- SHIBATA Katsumi
- Department of Nutrition, School of Human Culture, The University of Shiga Prefecture
書誌事項
- タイトル別名
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- Time-Dependent Effects of <small>L</small>-Tryptophan Administration on Urinary Excretion of <small>L</small>-Tryptophan Metabolites
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抄録
We have previously reported that dietary supplementation with up to 5.0 g/d of L-tryptophan (L-Trp) for 21 d has no adverse effects, judging from the levels of general blood variables, in healthy women. We performed a randomized, double-blind, placebo-controlled, crossover intervention study in 17 apparently healthy Japanese women. The subjects were randomly assigned to receive a placebo (0 g/d) or 1.0, 2.0, 3.0, 4.0, or 5.0 g/d of L-Trp for 21 d each with a 5-wk washout period between trials. We examined the 24-h urine profiles on days −1 (1 d before starting L-Trp), 7, 14, and 21 to determine whether administration of L-Trp at doses of up to 5.0 g/d affects time-dependent urinary excretion of L-Trp or its metabolites in healthy women. The urinary excretion of L-Trp, kynurenic acid, 3-hydroxykynurenine, xanthurenic acid, 3-hydroxyanthranilic acid, quinolinic acid, N1-methylnicotinamide, N1-methyl-2-pyridone-5-carboxamide, and N1-methyl-4-pyridone-3-carboxamide increased in an L-Trp dose-dependent manner on day 7. The amount of urinary excretion of these compounds was unchanged on days 14 and 21. The urinary excretion of serotonin, 5-hydroxyindole-3-acetic acid, 2-oxoadipic acid, and nicotinamide was unaffected by L-Trp at any of the doses tested. L-Trp doses had weak effects on the urinary excretion of kynurenine and anthranilic acid. Based on these findings, we conclude that there are no time-dependent effects of L-Trp administration in urinary excretion of L-Trp metabolites. Additionally, L-Trp and its metabolites do not accumulate in the body.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 60 (4), 255-260, 2014
一般財団法人 学会誌刊行センター
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詳細情報 詳細情報について
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- CRID
- 1390001206324486272
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- NII論文ID
- 130004695717
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- NII書誌ID
- AA00703822
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- COI
- 1:CAS:528:DC%2BC2cXhsFaksr7M
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- ISSN
- 18817742
- 03014800
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- NDL書誌ID
- 025737096
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- PubMed
- 25297614
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可