アストロサイトによるカリウム輸送のシミュレーション解析

• 村上 慎吾

• 倉智 嘉久

書誌事項

タイトル別名

• Simulation analysis on astrocytic K+ buffering

抄録

In response to the elevation of extracellular K ⁺ concentration ([K⁺] _out), astrocytes clear excessive K ⁺ to maintain conditions necessary for neural activity. Despite the importance of astrocytic K ⁺ clearance, the underlying mechanisms remain unclear. Here we report results from a simulation analysis of astrocytic K ⁺ clearance. Astrocyte models were constructed by incorporating various mechanisms such as intra/extracellular ion concentrations of Na ⁺, K ⁺, and Cl ^-, cell volume, and models of Na,K-ATPase, Na-K-Cl cotransporter (NKCC), K-Cl cotransporter, inwardly-rectifying K⁺ (KIR) channel, passive Cl^- current, and Aquaporin channel. The simulated response of astrocyte models under high [K⁺]_out revealed significant contributions of NKCC and Na,K-ATPase to increases of intracellular K ⁺ and Cl ^- concentrations. Moreover, we found that KIR channels localized at synaptic clefts absorbed excess K⁺, while K ⁺ released through perivascular KIR channels was enhanced.

収録刊行物

• 生体医工学

  生体医工学 52 (Supplement), O-414-O-415, 2014

  公益社団法人 日本生体医工学会

詳細情報

• CRID: 1390282680243906560
• NII論文ID: 130004695851
• DOI: 10.11239/jsmbe.52.o-414
• ISSN: 18814379
• ISSN: 1347443X
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可