Nontuberculous Mycobacterium Diseases and Chronic Thromboembolic Pulmonary Hypertension
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- Kuroda Fuminobu
- Department of Respiratory Medicine, Chibaken Saiseikai Narashino Hospital, Japan Department of Respirology, Graduate School of Medicine, Chiba University, Japan
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- Tanabe Nobuhiro
- Department of Respirology, Graduate School of Medicine, Chiba University, Japan
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- Igari Hidetoshi
- Department of Respiratory Medicine, National Hospital Organization Chiba-East National Hospital, Japan
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- Sakurai Takayuki
- Department of Respirology, Graduate School of Medicine, Chiba University, Japan
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- Sakao Seiichiro
- Department of Respirology, Graduate School of Medicine, Chiba University, Japan
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- Tada Yuji
- Department of Respirology, Graduate School of Medicine, Chiba University, Japan
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- Kasahara Yasunori
- Department of Respirology, Graduate School of Medicine, Chiba University, Japan
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- Tatsumi Koichiro
- Department of Respirology, Graduate School of Medicine, Chiba University, Japan
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Objective We aimed to investigate the incidence and clinical characteristics of nontuberculous mycobacterial (NTM) pulmonary disease as a complication of chronic thromboembolic pulmonary hypertension (CTEPH).<br> Methods We conducted a retrospective study of 10 cases (5.6%) complicated by NTM pulmonary disease among 180 CTEPH patients.<br> Results Isolated species of avium (n=5), kansasii (n=2), intracellulare (n=1), abscessus (n=1) and fortuitum (n=1) were detected. NTM-infected lesions were observed in 33 of 180 (18.3%) lung segments obtained from the 10 patients, and complete obstruction due to chronic pulmonary thromboembolism was detected in 65 of the 180 segmental pulmonary arteries (36.1%). The NTM-infected segments in the CTEPH patients were significantly associated with obstructed rather than unobstructed pulmonary artery segments [25 of 65 (38.5%) vs. 8 of 115 (6.9%), p<0.01]. Cavitary, nodular, ectatic and ground-glass lesions were seen in 14, 22, seven and four of the 180 segments, respectively. Thirteen of the 14 cavitary (92.9%) lesions were located in non-perfused segments. Five patients with NTM disease underwent pulmonary endarterectomy (PEA). Of the 18 assessable NTM-infected segments in six NTM-treated patients, 17 were located in non-perfused segments and one was located in a previously perfused segment. All NTM-infected segments improved among three segments reperfused with PEA. In contrast, only eight (57.1%) NTM-infected segments improved among 14 continuously non-perfused segments. A lower body mass index was found to be a significant risk factor for NTM disease in the CTEPH patients.<br> Conclusion This is the first report to document NTM-disease complications in patients with CTEPH. Reperfusion in cases of NTM lesions may improve the response to NTM drug therapy.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 53 (20), 2273-2279, 2014
一般社団法人 日本内科学会