Association Between KCNJ6 (GIRK2) Gene Polymorphism rs2835859 and Post-operative Analgesia, Pain Sensitivity, and Nicotine Dependence

• Nishizawa Daisuke

  Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Japan

• Fukuda Ken-ichi

  Department of Dental Anesthesiology, Tokyo Dental College, Japan

• Kasai Shinya

  Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Japan

• Ogai Yasukazu

  Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Japan

• Hasegawa Junko

  Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Japan

• Sato Naomi

  Department of Clinical Nursing, Hamamatsu University School of Medicine, Japan Department of Tumor Pathology, Hamamatsu University School of Medicine, Japan

• Yamada Hidetaka

  Department of Tumor Pathology, Hamamatsu University School of Medicine, Japan

• Tanioka Fumihiko

  Department of Pathology, Iwata City Hospital, Japan

• Sugimura Haruhiko

  Department of Tumor Pathology, Hamamatsu University School of Medicine, Japan

• Hayashida Masakazu

  Department of Anesthesiology & Pain Medicine, Juntendo University School of Medicine, Japan

• Ikeda Kazutaka

  Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Japan

書誌事項

タイトル別名

• Association Between <i>KCNJ6</i> (<i>GIRK2</i>) Gene Polymorphism rs2835859 and Post-operative Analgesia, Pain Sensitivity, and Nicotine Dependence
• Association between KCNJ6 (GIRK2) gene polymorphism rs2835859 and postoperative analgesia, pain sensitivity, and susceptibility to nicotine dependence

抄録

G-protein–activated inwardly rectifying potassium (GIRK) channels are expressed in many tissues and activated by several G_i/o protein–coupled receptors, such as opioid and dopamine receptors, and thus are known to be involved in the modulation of opioid-induced analgesia, pain, and reward. We focused on a GIRK-channel subunit that plays a pivotal role in the brain, GIRK2, and investigated the contribution of genetic variations of the GIRK2 (KCNJ6) gene to individual differences in the sensitivity to opioid analgesia. In our initial linkage disequilibrium analysis, a total of 27 single-nucleotide polymorphisms (SNPs) were selected within and around the regions of the KCNJ6 gene. Among them, the rs2835859 SNP, for which associations with analgesia and pain have not been previously reported, was selected in the exploratory study as a potent candidate SNP associated with opioid analgesic sensitivity. The results were corroborated in further confirmatory study. Interestingly, this SNP was also found to be associated with sensitivity to both cold and mechanical pain, susceptibility to nicotine dependence, and successful smoking cessation. The results indicate that this SNP could serve as a marker that predicts sensitivity to analgesic and pain and susceptibility to nicotine dependence.

収録刊行物

• Journal of Pharmacological Sciences

  Journal of Pharmacological Sciences 126 (3), 253-263, 2014

  公益社団法人 日本薬理学会

キーワード

• G-protein–activated inwardly rectifying potassium (GIRK) channel
• single-nucleotide polymorphism
• opioid analgesia
• pain
• susceptibility to nicotine dependence

詳細情報

• CRID: 1390282680157490432
• NII論文ID: 130004700283
• NII書誌ID: AA11806667
• DOI: 10.1254/jphs.14189fp
• ISSN: 13478648
• ISSN: 13478613
• NDL書誌ID: 025925070
• PubMed: 25346042
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I025925070
• Web Site: https://www.jstage.jst.go.jp/article/jphs/126/3/126_14189FP/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2015248649
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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