広範囲進展口腔癌に対して血流改変術を併用した従来型の選択的動注化学・放射線療法が有効であった1例

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  • A successful case of treatment of widespread oral cancer with arterial redistribution by traditional selective intra-arterial chemoradiotherapy
  • コウハンイ シンテン コウコウガン ニ タイシテ ケツリュウ カイヘンジュツ オ ヘイヨウ シタ ジュウライ カタ ノ センタクテキドウ チュウ カガク ・ ホウシャセン リョウホウ ガ ユウコウ デ アッタ 1レイ

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In recent years, anticancer drug treatment with traditional selective intra-arterial chemotherapy has attracted little attention. We report an advanced case of oral cancer successfully treated by traditional selective intra-arterial chemoradiotherapy with arterial redistribution technique. The patient, a 67-year-old man, complained of tongue pain and eating disorder on initial consultation. An inspection was conducted immediately, and right-sided tongue carcinoma (T4bN2bM0) was diagnosed. Angiography showed that tumor nutrient arteries, facial artery and lingual artery had a common trunk with angiectopia. We expected that insertion of a catheter into the tumor nutrient arteries would prove difficult, so traditional selective intra-arterial injection chemotherapy with arterial redistribution was planned. Intra-arterial chemotherapy was performed for 5 weeks using 5-fluorouracil (100-50 mg/m2/day; total, 8856 mg), docetaxel (15 mg/m2/week; total, 178.2 mg), and nedaplatin (20 mg/m2/week; total, 225.3 mg) combined with radiotherapy (total, 50 Gy). After the completion of treatment, the tumor mass and ulcer disappeared from the oral cavity. As of 18 months after treatment, follow-up has shown no recurrence or metastasis. This treatment was able to achieve an effect comparable to superselective intra-arterial chemoradiotherapy.

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