Development of Primary Central Nervous System Lymphoma Associated with Human Immunodeficiency Virus and JC Virus Infection
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- Kawakami Toru
- Department of Hematology, NHO Matsumoto Medical Center
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- Sakai Kaoko
- Division of Hematology, Department of Internal Medicine, Shinshu University School of Medicine
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- Mimura Yuto
- Department of Hematology, NHO Matsumoto Medical Center
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- Senoo Yasushi
- Department of Hematology, NHO Matsumoto Medical Center
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- Hirabayashi Yukio
- Department of Hematology, NHO Matsumoto Medical Center
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- Nakazawa Hideyuki
- Department of Hematology, NHO Matsumoto Medical Center
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- Koshihara Hiroshi
- Department of Neurology, NHO Matsumoto Medical Center
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- Oguchi Kenya
- Department of Neurology, NHO Matsumoto Medical Center
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- Takei Yo-ichi
- Department of Neurology, NHO Matsumoto Medical Center
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- Ohara Shinji
- Department of Neurology, NHO Matsumoto Medical Center
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- Watanabe Nobuaki
- Department of Neurosurgery, NHO Matsumoto Medical Center
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- Nakazawa Kou
- Department of Laboratory Medicine, NHO Matsumoto Medical Center
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- Oyanagi Kiyomitsu
- Division of Neuropathology, Department of Brain Disease Research, Shinshu University School of Medicine
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- Kitano Kiyoshi
- Department of Hematology, NHO Matsumoto Medical Center
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We report here a case of a 37-year-old man with human immunodeficiency virus (HIV) infection followed by JC virus (JCV) infection and primary central nervous system lymphoma (PCNSL). The patient had been infected with HIV type 1 due to blood products for hemophilia A during infancy. He had progression of nervous symptoms and was diagnosed with progressive multifocal leukoencephalopathy (PML) clinically at the age of 36, when his CD4-positive lymphocyte counts ranged between 350 and 450/μl. Oral mefloquine, intravenous methylprednisolone pulse therapy, and intravenous immunoglobulin were not effective for the PML, and the patient entered a vegetative state. Brain biopsy revealed JCV infection without pathological findings of PML. Eight months after the clinical diagnosis of PML, he developed respiratory failure and brain magnetic resonance imaging revealed a mass lesion in the brain stem. The patient died 19 months after the diagnosis of PML. Autopsy findings were compatible with PCNSL. EBV-encoded small RNA-1-positive cells were not detected. We present a case of JCV-positive PCNSL with HIV infection complicated with clinical PML.
収録刊行物
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- Journal of Clinical and Experimental Hematopathology
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Journal of Clinical and Experimental Hematopathology 54 (3), 211-217, 2014
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詳細情報
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- CRID
- 1390282679682365440
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- NII論文ID
- 130004705268
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- ISSN
- 18809952
- 13464280
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- PubMed
- 25501112
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可