実験的エストロゲン過剰症に於ける病理組織学的研究

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  • Pathohistological Study on the Experimental Hyperestrogenism

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After a certain period following castration groups of mature female rabbits were injected aubcutaneously at their back with 15 mg of estrogen pellet 1, 2, 3, 4 and 9 times at intervals of every 2 weeks, killed 2 weeks after the final administration and divided into 5 groups of 2 to 4 rabbits each according to total doses of 15 to 135 mg and periods of 2 to 18 weeks administered to produce the experimental hyperestrongenism with progesteron effect intercepted. Meanwhile, in order to confirm effccts of castration at each period, pathological, anatomical and histological examination were conducted chiefly on their uterus, mammary gland, pituitary body, thyroid gland, suprarenal gland, kidney and liver together with those of 5 control groups of 2 castrated animals each. Experimental results were classified roughly into two categories according to dose of estrogen and period administered. (1) In groups administered with 15 to 45 mg of estrogen pellet for 2 to 6 weeks 2 weeks after castration the endometrium atrophined and thinned by castration indicated a remarkable glandular proliferation, and the muscularis mucosae thinned was also hyperthophied several times. Until 6 weeks after castration the mammary gland not different from non-functional and normal control proliferated like fibroadenia and acinar adenosis, and the abmornally proliferated focus of galactophorous glands was noted. Up to 6 weeks after castration appearance of acidophile celles instead of basophile cells became remarkable in the anterior hypophysis where the latter was to proliferate, chromophobic cells also developed and eflect of castration was inhibited by administration of estrogen. The cortex became slightly hypertropeied 2 to 4 weeks after castration. Four weeks later fat decreased in the fascicular Layer of suprarenal cortex, but a large amount of fat was still encountered in the coniform layer of suprarenal cortex. However, continual decrease of fat was found in the fascicular Layer, and cells were hypertrophied from the depth to the reticular layer. The thyroid gland was reduced in function, was concentrated in colloid, and indicated large follicles due to castration. But it was weakened in the colloid, indicated small follicles and was enhanced in function due to administration of estrogen. Extending over prolonged period after castration binuclear cells developed in atrophied liver, while central vein and venous sinus were congested and enlarged. Estrogen had no effect on the spleen where there was noted no remarkable cnange after castration. Degenerated epithelium of the principal part of the nephritic duct, which became distinct 2 to 4 weeks after castration, was recoverd by administration of estrogen. (2) In groups administered with 60 to 135 mg of estrogen pellet for 8 to 18 weeks after castration the endometrium was markedly infiltrated with leukocytes showing the necroosis or the necrobiosis. The infiltra tion extended into the muscularis mucosae, and vein and cepillara of the uterine vagina were markedly congested and enlarged, part of them indicating the thrombosis. However, the residual muscularis mucosae was rather proliferative, and in groups administered with 135 mg of the medicine for 8 weeks the fibroma was formed below the serous membrane. In the mammary glands where rami of the galactophorous ducts temporarily exteded and the epithelium proliferated, lobules collapsed completely and large cystic mastopathy seemed to appear. In the anterior hypophysis surrounded by the stroma acidophile cells decreased and collapsed, while basophile cells diminished markedly and chromophobic cells increased remarkably instead. Fat in the coniform layer of the suprarenal cortex disappeared entirely, but a considerable amount of fat was noted in the fascicular layer. Concentration, collapse and disappearance of cytoblasts were noted.

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