Waldenström's Macroglobulinemia Accompanying Systemic Amyloidosis: The Usefulness of Endobronchial Ultrasound-guided Transbronchial Needle Aspiration for Detecting Amyloid Deposits
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- Ishiguro Takashi
- Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan
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- Takayanagi Noboru
- Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan
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- Katoh Nagaaki
- Department of Neurology and Rheumatology, Shinshu University, Japan
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- Shimizu Yoshihiko
- Department of Pathology, Saitama Cardiovascular and Respiratory Center, Japan
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- Hoshi Toshiko
- Department of Radiology, Saitama Cardiovascular and Respiratory Center, Japan
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- Yanagisawa Tsutomu
- Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan
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- Sugita Yutaka
- Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan
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抄録
A 75-year-old man with a history of dyspnea lasting for three years presented to our hospital. Chest computed tomography showed bilateral pulmonary nodules, some of which were calcified, in addition to mediastinal/hilar lymphadenopathy and bilateral pleural effusions. Endobronchial ultrasound-guided (EBUS) transbronchial needle aspiration (TBNA) of the subcarinal lymph nodes showed amorphous acellular material compatible with λ-light chain amyloid deposits. Sternal bone marrow aspiration demonstrated increased small lymphocytes admixed with plasma cells and plasmacytoid lymphocytes. Serum immunoglobulin values were decreased with the exception of immunoglobulin M monoclonal peak. We subsequently diagnosed the patient as having Waldenström's macroglobulinemia accompanying AL-type amyloidosis. In this case, EBUS-TBNA was useful for detecting AL-type amyloidosis.<br>
収録刊行物
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- Internal Medicine
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Internal Medicine 53 (24), 2789-2793, 2014
一般社団法人 日本内科学会
