The Effect of Lactic Acid Bacteria on Atopic Dermatitis

DOI
  • Fujimura Takao
    Department of Dermatology, Kitasato University School of Medicine

Bibliographic Information

Other Title
  • アトピー性皮膚炎に対する乳酸菌の効果

Search this article

Abstract

The recent health food craze has lead to the availability of a wide variety of health foods, including items that are expected to moderate the symptoms of various allergic diseases, such as atopic dermatitis (AD) and allergic rhinitis. Lactic acid bacteria, in particular, are attracting attention due to its favorable effect on AD in pregnant women and newborns as reported by Kalliomkái et al.<BR>Immunologically, AD is a Th2 dominant disease. Its clinical course changes along with the balance between Th1 and Th2. Previously, we analyzed cases where patients of intractable AD experienced some moderation in symptoms over several months after being infected with varicella or measles. IL-12, produced in the eruption area to eradicate the infecting virus, acts on mite antigen responsive Th2 cells, switching the cytokine production pattern from Th2 type to Th1 type. It was concluded that this change in the balance of Th2 to Th1 lead to the moderation of AD.<BR>Recently, in collaboration with the Functional Foods Division of Combi Corporation, lactic acid strains with strong IL-12 stimulation capability were identified, and the effect of lactic acid on allergic diseases were studied in animal and clinical experiments. NC mice were fed with lactic acid daily. Changes in skin conditions and the total IgE value in NC mice were observed over time. Fluctuations in antigen-specific IgE value and eosinophils counts were also studied using model mice with OVA-induced asthma. Moderation in AD skin conditions and suppression of IgE value were found in NC mice, and lower antigen-specific IgE and suppressed eosinophils accumulation in asthma model mice. In clinical tests, some preliminary improvement in symptoms and lower antigen-specific IgE value were observed in limited cases. In this seminar, these data will be introduced, and the effect of lactic acid on AD will be discussed.

Journal

  • Hifu no kagaku

    Hifu no kagaku 7 (Suppl.10), A38-A44, 2008

    Meeting of Osaka Dermatological Association/Meeting of Keiji Dermatological Association

Keywords

Details 詳細情報について

Report a problem

Back to top